A-Calm Tablet 50 mg contains Tolperisone Hydrochloride, a centrally acting muscle relaxant used for the relief of painful muscle spasms associated with acute and chronic musculoskeletal conditions. It works by reducing increased muscle tone without causing significant sedation, making it suitable for patients who require muscle relaxation while maintaining normal daily activities.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Calm Tablet 50 mg is indicated for the treatment of muscle spasticity and associated pain in various conditions, including:

• Acute painful muscle spasms

• Chronic musculoskeletal disorders

• Low back pain

• Cervical and lumbar spondylosis

• Post-traumatic muscle spasm

• Post-operative muscle stiffness

• Neurological conditions associated with increased muscle tone

By relieving muscle tension, A-Calm Tablet helps improve mobility and reduces discomfort, thereby enhancing quality of life.

Therapeutic Class

Centrally acting muscle relaxants

Pharmacology

Tolperisone Hydrochloride acts primarily at the level of the central nervous system, particularly the spinal cord. It stabilizes neuronal membranes and inhibits abnormal reflex activity responsible for muscle spasticity. Unlike many other muscle relaxants, tolperisone has minimal sedative properties, allowing patients to remain alert during treatment.

The drug reduces pathological muscle tone by decreasing excessive nerve impulses to skeletal muscles. It also has mild vasodilatory properties, which may contribute to improved blood flow in affected muscles and enhanced relief from pain and stiffness.

Mode of Action

Tolperisone inhibits voltage-gated sodium and calcium channels in nerve fibers, thereby suppressing the transmission of excitatory impulses in the spinal reflex pathways. This results in relaxation of skeletal muscles, reduction of muscle stiffness, and alleviation of pain associated with muscle spasm.

Dosage and Administration

Dosage should be individualized based on the severity of symptoms and patient response:

• Adults: Usually 50 mg taken two to three times daily after meals

• Dose may be adjusted gradually under medical supervision

A-Calm Tablet should be swallowed whole with water and taken after food to reduce gastrointestinal discomfort.

Drug Interactions

Tolperisone generally has a low potential for drug interactions. However, caution is advised when used with other centrally acting agents. Dose adjustment may be required when used concomitantly with nonsteroidal anti-inflammatory drugs (NSAIDs).

Contraindications

A-Calm Tablet 50 mg is contraindicated in patients with:

• Known hypersensitivity to tolperisone or any component of the formulation

• Myasthenia gravis

• Severe hepatic impairment

Side Effects

A-Calm Tablet is usually well tolerated. Some patients may experience mild to moderate side effects, including:

• Dizziness

• Headache

• Nausea

• Gastrointestinal discomfort

• Muscle weakness (rare)

• Hypersensitivity reactions such as rash or itching

Most side effects are transient and resolve with continued use or dose adjustment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

The use of A-Calm Tablet during pregnancy and lactation should be based on a physician’s assessment of benefit versus risk. It is generally advised to use tolperisone with caution in pregnant and breastfeeding women.

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.