Amdocal 5 mg is a long-acting calcium channel blocker that helps relax blood vessels and improve blood flow, reducing blood pressure and alleviating angina. It may be used alone or in combination with other antihypertensive or antianginal agents for the treatment of hypertension and coronary artery disease. Amdocal 5 mg is effective in patients with chronic stable angina, vasospastic angina, and angiographically documented coronary artery disease without heart failure or reduced ejection fraction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Amdocal 5 mg is indicated for:

• Hypertension (high blood pressure)

• Coronary artery disease (CAD), including:

  • Chronic stable angina

  • Vasospastic (Prinzmetal’s) angina

  • Angiographically documented CAD in patients without heart failure or ejection fraction <40%

Therapeutic Class

Calcium-channel blockers

Pharmacology

Amdocal 5 mg inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. By relaxing vascular smooth muscles, it reduces peripheral vascular resistance and lowers blood pressure. Its antianginal effect is attributed to:

• Peripheral arteriole dilation, reducing afterload and myocardial oxygen consumption

• Dilation of coronary arteries and arterioles, improving oxygen delivery in ischemic regions

These combined actions reduce total ischemic burden without significantly affecting heart rate.

Dosage and Administration

Adults:

• Starting dose: 5 mg once daily

• Maximum dose: 10 mg once daily

Pediatric patients (6–17 years):

• Starting dose: 2.5 mg once daily, titrated to 5 mg once daily if needed

Elderly, fragile, or hepatic impairment:

• Starting dose: 2.5 mg once daily, titrate carefully

Administration tips:

• Take at the same time each day

• Can be administered with or without food

Drug Interactions

• Compatible with thiazide diuretics, alpha blockers, beta blockers, ACE inhibitors, nitrates, sublingual nitroglycerin, NSAIDs, antibiotics, and oral hypoglycemics

• Avoid grapefruit or grapefruit juice as it may increase bioavailability and blood pressure-lowering effects

Contraindications

• Known hypersensitivity to Amdocal 5 mg or amlodipine

• Severe aortic stenosis or cardiogenic shock (use with caution)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common:

• Headache

• Peripheral edema (dose-related)

• Fatigue

• Nausea

• Abdominal pain

• Somnolence

Rare:

• Palpitations, flushing, dizziness, rash, constipation, or diarrhea

Precautions and Warnings

• Symptomatic hypotension is possible, especially in severe aortic stenosis

• Worsening angina or myocardial infarction may occur after initiating or increasing dose in patients with severe CAD

• Slow titration recommended in hepatic impairment

• Monitor cardiovascular status in patients with severe comorbidities

Overdose

Symptoms may include: excessive peripheral vasodilation, reflex tachycardia, hypotension, and shock. Management includes:

• Cardiovascular support

• Elevation of extremities and fluid management

• Vasoconstrictors if indicated

• Intravenous calcium gluconate may reverse calcium channel blockade effects

• Activated charcoal may reduce absorption if given within 2 hours

Pregnancy and Lactation

• Pregnancy Category C: Use only if benefits outweigh potential risks

• Safety in breastfeeding not established; discontinue nursing if treatment is necessary

Storage Conditions

Store in a dry place away from light and heat.
Keep out of reach of children.

Mode of Action

Amdocal 5 mg blocks calcium entry into cardiac and vascular smooth muscle cells, leading to vasodilation, reduced peripheral resistance, and decreased myocardial oxygen demand, improving blood pressure and angina control.