Angirid MR Tablet 35 mg contains Trimetazidine Dihydrochloride, a metabolic anti-ischemic agent used as an adjunct treatment for angina pectoris. Unlike conventional antianginal drugs that act mainly on heart rate or blood pressure, Angirid MR works at the cellular level to improve myocardial energy metabolism. The modified-release (MR) formulation ensures sustained drug delivery, providing prolonged therapeutic effect and better symptom control throughout the day.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Trimetazidine Dihydrochloride

• Strength: 35 mg

• Dosage Form: Modified-release oral tablet

Therapeutic Class

• Metabolic Antianginal Agent

• Anti-ischemic cardiovascular medicine

Indications

Angirid MR Tablet 35 mg is indicated for:

• Chronic Stable Angina Pectoris as add-on therapy

• Management of myocardial ischemia when conventional antianginal treatment is insufficient

• Improvement of exercise tolerance and reduction in frequency of angina attacks

• Long-term supportive therapy in ischemic heart disease

Pharmacology

Trimetazidine acts by optimizing cardiac energy metabolism during ischemic conditions. It selectively inhibits fatty acid oxidation and shifts myocardial energy production toward glucose oxidation, which requires less oxygen to generate the same amount of energy. This metabolic shift helps maintain adequate ATP levels in heart muscle cells, thereby protecting them from ischemic damage.

By preserving cellular energy balance, Angirid MR improves myocardial efficiency without affecting heart rate, blood pressure, or coronary blood flow. The modified-release formulation allows gradual drug release, ensuring consistent plasma levels and sustained antianginal action over 24 hours.

Dosage and Administration

• The usual recommended dose is 35 mg twice daily, preferably taken with meals.

• Tablets should be swallowed whole and not crushed or chewed to maintain the modified-release property.

• Dosage adjustments may be necessary in elderly patients or those with renal impairment, as advised by a physician.

Side Effects

Angirid MR Tablet is generally well tolerated. Some patients may experience:

• Dizziness

• Headache

• Nausea or abdominal discomfort

• Fatigue

• Rarely, movement disorders such as tremor or rigidity with long-term use

Most side effects are mild and reversible upon discontinuation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not intended for the acute relief of angina attacks.

• Use with caution in patients with renal impairment; dose adjustment may be required.

• Should be avoided in patients with Parkinson’s disease or movement disorders.

• Not recommended during pregnancy and breastfeeding unless clearly prescribed by a physician.

Drug Interactions

Clinically significant drug interactions are uncommon. Angirid MR can be safely used alongside beta-blockers, nitrates, calcium channel blockers, and other standard antianginal therapies.

Storage Conditions

• Store in a cool, dry place below 30°C

• Protect from moisture and direct sunlight

• Keep out of reach of children.