Arlin 2 mg/ml is a parenteral formulation of Linezolid, belonging to the oxazolidinone class of antibiotics. It is a synthetic, broad-spectrum antibacterial agent designed to target Gram-positive aerobic bacteria, select Gram-positive anaerobes, and certain Gram-negative bacteria. Arlin 2 mg/ml is commonly used in serious hospital-acquired infections, especially those caused by drug-resistant pathogens like vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA).

It is available as an intravenous solution for patients who cannot take oral therapy, and can be transitioned seamlessly to oral Linezolid without dose adjustment due to its high oral bioavailability (~100%).

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Arlin 2 mg/ml is indicated for the treatment of:

• Vancomycin-Resistant Enterococcus faecium (VRE) infections, including concurrent bacteremia

• Nosocomial pneumonia caused by Staphylococcus aureus (MSSA & MRSA) or Streptococcus pneumoniae, including multi-drug resistant strains

• Complicated skin and soft tissue infections, including diabetic foot infections (without osteomyelitis) caused by S. aureus (MSSA & MRSA), Streptococcus pyogenes, or Streptococcus agalactiae

• Uncomplicated skin and soft tissue infections caused by S. aureus (MSSA) or Streptococcus pyogenes

• Community-acquired pneumonia, including concurrent bacteremia, caused by S. pneumoniae (multi-drug resistant strains) or S. aureus (MSSA only)

Therapeutic Class

• Oxazolidinone antibiotic (macrolide-like properties)

Pharmacology

Arlin 2 mg/ml selectively inhibits bacterial protein synthesis by binding to the 23S rRNA of the 50S subunit of the bacterial ribosome. This prevents the formation of the 70S initiation complex, essential for bacterial translation.

• Bacteriostatic against enterococci and staphylococci

• Bactericidal against most streptococcal strains

• Effective against multi-drug resistant Gram-positive bacteria

Dosage & Administration

Adults and Adolescents (≥12 years):

• Complicated skin infections / Community-acquired pneumonia: 600 mg IV every 12 hours, 10–14 days

• Nosocomial pneumonia / VRE infections: 600 mg IV every 12 hours, 14–28 days

• Uncomplicated skin infections: 400–600 mg IV every 12 hours, 10–14 days

Pediatric Patients:

• Birth to 11 years: 10 mg/kg IV every 8–12 hours depending on age and infection type

• Neonates (<7 days): 10 mg/kg IV every 12 hours; may adjust to every 8 hours if needed

Administration Notes:

• IV infusion: Administer over 30–120 minutes; do not mix with other additives or use in series connections

• Oral switch: No dose adjustment required due to 100% bioavailability

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Monoamine oxidase inhibition: Arlin 2 mg/ml is a reversible, nonselective MAO inhibitor

• Adrenergic agents: May enhance pressor response; start with reduced doses

• Serotonergic agents: Risk of serotonin syndrome; monitor for cognitive changes, hyperreflexia, and hyperpyrexia

Contraindications

• Hypersensitivity to Linezolid or components

• Use with MAO inhibitors (within 2 weeks)

• Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome

• Concomitant use with certain adrenergic or serotonergic drugs (e.g., pseudoephedrine, SSRIs, triptans, meperidine)

Side Effects

Common: Diarrhea, headache, nausea
Other reported: Oral/vaginal candidiasis, hypertension, dyspepsia, abdominal pain, pruritus, tongue discoloration
Rare: Convulsions, visual disturbances, serotonin syndrome

Precautions & Warnings

• Monitor for recurrent nausea, vomiting, unexplained acidosis

• Watch for signs of serotonin syndrome with serotonergic drugs

• Ophthalmic evaluation recommended for visual changes

• Convulsions may occur in patients with seizure history or risk factors

Pregnancy & Lactation

• Pregnancy Category C: Use only if potential benefits outweigh risks

• Unknown excretion in human milk; exercise caution while nursing

Storage Conditions

• Store at 15–30°C, protected from light and moisture

• Keep out of reach of children.