Avifanz Tablet 600 mg contains Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in the treatment of Human Immunodeficiency Virus type-1 (HIV-1) infection. Efavirenz is a key component of antiretroviral therapy (ART) and is usually prescribed in combination with other antiretroviral medicines to achieve effective viral suppression and improve immune function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Indication

Avifanz Tablet 600 mg is indicated for:

• Treatment of HIV-1 infection in adults and adolescents

• Use as part of combination antiretroviral therapy (ART)

• Long-term management of HIV to reduce viral load and delay disease progression

Efavirenz does not cure HIV but helps control the virus and reduces the risk of HIV-related complications.

Mechanism of Action

Efavirenz works by selectively inhibiting HIV-1 reverse transcriptase, an enzyme essential for viral replication. It binds directly to the enzyme and blocks the conversion of viral RNA into DNA. This prevents the virus from multiplying within human immune cells, leading to:

• Reduced viral replication

• Lower plasma HIV viral load

• Preservation and improvement of CD4 cell counts

Efavirenz has no significant activity against HIV-2.

Dosage and Administration

• The usual recommended dose is 600 mg once daily.

• Avifanz Tablet should be taken on an empty stomach, preferably at bedtime, to reduce central nervous system (CNS) side effects.

• It must always be used in combination with other antiretroviral agents.

Patients should take the medicine regularly as prescribed to avoid treatment failure and resistance.

Benefits and Features

• Potent and long-acting antiretroviral agent

• Once-daily dosing improves patient compliance

• Effectively suppresses HIV-1 viral replication

• Plays a key role in standard ART regimens

• Helps improve quality of life and life expectancy in HIV patients

Use in Special Populations

• Pregnancy: Efavirenz should be used during pregnancy only if clearly recommended by a healthcare professional due to potential risks.

• Breastfeeding: Not recommended, as HIV can be transmitted through breast milk.

• Liver impairment: Use with caution and regular monitoring of liver function is required.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

Avifanz Tablet 600 mg should be used cautiously in patients with:

• Liver disease or hepatitis B or C co-infection

• Psychiatric disorders such as depression or psychosis

• History of seizures

Patients should be advised to avoid alcohol and to report any unusual mood changes, hallucinations, or sleep disturbances.

Possible Side Effects

Common side effects may include:

• Dizziness, headache, or fatigue

• Abnormal dreams or insomnia

• Nausea, vomiting, or diarrhea

• Skin rash

Less common but serious effects include liver toxicity and severe psychiatric symptoms. Most CNS effects are mild to moderate and tend to decrease after the first few weeks of therapy.

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children.