Azofend Tablet 50 mg contains Voriconazole, a broad-spectrum antifungal medication used to treat serious fungal infections. Voriconazole belongs to the triazole class of antifungal agents and works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting the fungal cell membrane, it effectively halts fungal growth and replication, making it a potent option for treating invasive and systemic fungal infections.

Azofend is prescribed for both immunocompromised and immunocompetent patients with severe fungal infections. It is particularly useful in cases where infections are resistant to conventional antifungal therapies or when rapid fungal eradication is necessary.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antifungal Agent

• Triazole Derivative

Indications

Azofend Tablet 50 mg is indicated for the treatment of:

• Invasive aspergillosis

• Candidemia and other serious Candida infections

• Esophageal candidiasis

• Scedosporium and Fusarium infections

• Other severe systemic fungal infections, especially in immunocompromised patients

• Prophylaxis of fungal infections in patients undergoing bone marrow or stem cell transplantation

Pharmacology

Voriconazole is a triazole antifungal that works by inhibiting fungal cytochrome P450-dependent 14α-lanosterol demethylation, a critical step in ergosterol biosynthesis. Lack of ergosterol compromises the integrity of the fungal cell membrane, leading to increased permeability and cell death.

Voriconazole exhibits broad-spectrum activity against various yeasts and molds, including Candida species, Aspergillus species, Fusarium, and Scedosporium. Its excellent tissue penetration makes it effective for systemic and invasive infections, including those affecting the lungs, bloodstream, central nervous system, and other organs.

Dosage and Administration

• Adults: Typical oral dose is 200 mg every 12 hours for the first day (loading dose), followed by 100 mg every 12 hours. Dosage may vary depending on infection severity, patient weight, and liver function.

• Children: Dosing is weight-based and should be determined by a specialist.

• Tablets should be taken at least one hour before or one hour after meals to ensure optimal absorption.

• Regular monitoring of liver function tests and plasma voriconazole levels is recommended for long-term therapy.

Contraindications

• Hypersensitivity to Voriconazole or other azole antifungals

• Concomitant use with drugs that are strongly contraindicated due to interactions (e.g., certain drugs metabolized by CYP3A4)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common adverse effects may include:

• Visual disturbances (blurred vision, altered color perception)

• Nausea, vomiting, or diarrhea

• Headache

• Elevated liver enzymes

• Skin rash

Serious adverse effects, although rare, may include hepatotoxicity, arrhythmias, and severe hypersensitivity reactions. Immediate medical attention is required if severe reactions occur.

Pregnancy and Lactation

• Voriconazole is not recommended during pregnancy unless benefits outweigh risks.

• Nursing mothers should avoid use, or discontinue breastfeeding during therapy due to potential drug excretion in breast milk.

Precautions and Warnings

• Monitor liver and renal function during therapy

• Caution in patients with pre-existing liver or kidney impairment

• Avoid excessive sunlight as photosensitivity reactions may occur

• Drug interactions are common; check concomitant medications

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children.