Caloplax Tablet 1 mg contains Prucalopride Succinate, a selective serotonin 5-HT4 receptor agonist, developed for the treatment of chronic idiopathic constipation (CIC) in adults. It is particularly effective in patients who have not responded adequately to conventional laxatives. By enhancing bowel motility, Caloplax Tablet promotes regular bowel movements, alleviates discomfort, and improves overall quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Prucalopride Succinate 1 mg

Therapeutic Class

• Gastrointestinal prokinetic agent

• Selective 5-HT4 receptor agonist

• Treatment of chronic constipation

Pharmacology and Mechanism of Action

Prucalopride, the active ingredient in Caloplax, is a highly selective 5-HT4 receptor agonist. By stimulating serotonin receptors in the gastrointestinal tract, it enhances peristaltic activity, accelerates colonic transit, and facilitates defecation.

Unlike traditional laxatives, which work by drawing water into the bowel or softening stool, prucalopride directly improves bowel motility at a physiological level. It acts primarily in the colon and has minimal effect on other organs, reducing the risk of systemic side effects.

Caloplax’s prokinetic action restores regular bowel movements, reduces bloating, and alleviates abdominal discomfort associated with chronic constipation.

Indications

Caloplax Tablet 1 mg is indicated for:

• Chronic idiopathic constipation (CIC) in adults

• Patients with inadequate response to conventional laxatives

• Improvement of bowel movement frequency, consistency, and overall bowel function

Dosage and Administration

Caloplax Tablet is taken orally, usually once daily with or without food. The recommended starting dose for adults is 1 mg per day. Tablets should be swallowed whole with water.

For patients with severe renal or hepatic impairment, dose adjustments may be required. Treatment duration is determined by the treating physician, depending on clinical response and symptom improvement.

Benefits

• Provides effective relief from chronic constipation

• Restores regular bowel movements and improves stool consistency

• Reduces bloating, straining, and abdominal discomfort

• Acts via a physiological mechanism for better gastrointestinal motility

• Suitable for long-term use under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not recommended for patients with mechanical gastrointestinal obstruction or severe inflammatory bowel disease

• Use with caution in patients with severe renal or hepatic impairment

• May cause mild gastrointestinal side effects such as diarrhea or abdominal pain initially

• Consult a physician if severe or persistent side effects occur

• Use during pregnancy and lactation only if clearly advised by a healthcare professional

Storage

Store below 30°C in a dry, cool place. Protect from light and moisture. Keep out of reach of children.