Cardicor Plus Tablet 5 mg+6.5 mg is a combination antihypertensive medication containing Bisoprolol Fumarate 5 mg and Hydrochlorothiazide 6.5 mg. It is formulated to provide enhanced blood pressure control by combining the effects of a beta-1 selective blocker with a thiazide diuretic, addressing both cardiac output and fluid balance.

Bisoprolol reduces heart rate and cardiac workload, while Hydrochlorothiazide increases urinary excretion of sodium and water, lowering blood volume and peripheral resistance. This dual mechanism makes Cardicor Plus effective for patients whose hypertension is not adequately managed with monotherapy, offering rapid and sustained blood pressure reduction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 5 mg – selective beta-1 adrenergic receptor blocker

• Hydrochlorothiazide 6.5 mg – thiazide diuretic

Mechanism of Action

Bisoprolol:

• Selectively blocks beta-1 adrenergic receptors in the heart

• Reduces heart rate, cardiac output, and myocardial oxygen demand

• Helps control tachycardia and arrhythmias associated with hypertension

Hydrochlorothiazide:

• Inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney

• Increases urinary excretion of sodium and water, reducing blood volume

• Lowers peripheral vascular resistance, contributing to sustained antihypertensive effect

Together, this combination addresses multiple mechanisms of hypertension, providing complementary and additive blood pressure reduction.

Indications

Cardicor Plus Tablet 5 mg+6.5 mg is indicated for:

• Essential hypertension – especially in patients unresponsive to monotherapy

• Hypertension with high cardiovascular risk – to reduce the risk of heart attack, stroke, and heart failure

• Patients with fluid retention associated with hypertension

• Heart rate control in hypertensive patients with tachycardia

Benefits

• Enhanced Blood Pressure Control: Combines beta-blocker and diuretic for effective reduction

• Dual Mechanism Therapy: Reduces both cardiac workload and blood volume

• Cardiovascular Protection: Lowers risk of stroke, myocardial infarction, and heart failure

• Convenient Once-Daily Dosing: Improves patient adherence and compliance

• Well-Tolerated: Beta-1 selectivity minimizes bronchospastic side effects; low-dose diuretic reduces risk of electrolyte imbalance

• Suitable for Combination Therapy: Ideal for patients who do not achieve target blood pressure with a single agent

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults: 1 tablet orally once daily, preferably at the same time each day

• Can be taken with or without food

• Dose adjustments may be required in elderly patients, or those with renal or liver impairment

• Regular monitoring of blood pressure, heart rate, electrolytes, and kidney function is recommended

• Do not stop therapy abruptly, as this may lead to rebound hypertension or angina exacerbation

Safety and Precautions

• Common side effects: dizziness, fatigue, headache, mild hypotension, increased urination, or cold extremities

• Rare side effects: bradycardia, electrolyte imbalance, severe hypotension, or allergic reactions

• Contraindicated in patients with severe bradycardia, heart block, cardiogenic shock, anuria, or hypersensitivity to either component

• Use with caution in patients with diabetes, gout, renal impairment, or severe liver disease

• Pregnant and breastfeeding women should use only under medical supervision

• Inform your physician about all concurrent medications to prevent potential interactions.