Clopid-AS Tablet 75 mg+75 mg is a fixed-dose combination of Clopidogrel and Aspirin, two well-established antiplatelet agents used to prevent the formation of harmful blood clots. This dual antiplatelet therapy is commonly prescribed for patients at high risk of cardiovascular and cerebrovascular events such as heart attack and stroke.

Clopidogrel works by selectively inhibiting the P2Y12 ADP receptor on platelets, thereby preventing platelet activation and aggregation. Aspirin, on the other hand, inhibits cyclooxygenase-1 (COX-1), reducing the production of thromboxane A2, a substance responsible for platelet aggregation and vasoconstriction. Together, these two medicines provide enhanced protection against clot formation by acting through complementary mechanisms.

Clopid-AS Tablet is particularly beneficial in patients who have experienced acute coronary syndrome (ACS), undergone coronary angioplasty with stent placement, or have a history of myocardial infarction or ischemic stroke.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Clopid-AS Tablet 75 mg+75 mg is indicated for:

• Prevention of heart attack (myocardial infarction)

• Prevention of ischemic stroke

• Management of acute coronary syndrome (unstable angina and NSTEMI/STEMI)

• Prevention of stent thrombosis after percutaneous coronary intervention (PCI)

• Secondary prevention in patients with established cardiovascular disease

This combination therapy significantly reduces the risk of recurrent cardiovascular events in high-risk individuals.

Dosage and Administration

The usual recommended dose is one tablet once daily, or as directed by a registered healthcare professional. The tablet should be swallowed whole with water and may be taken with or without food. Taking it with food may help minimize gastric discomfort caused by Aspirin.

Patients should follow their physician’s instructions carefully and should not discontinue the medication abruptly without medical advice, as this may increase the risk of thrombotic events.

Mechanism of Action

Clopidogrel is a prodrug that requires hepatic activation to exert its effect. Once activated, it irreversibly blocks platelet receptors, preventing ADP-mediated platelet aggregation. Aspirin irreversibly inhibits COX-1 enzyme activity, thereby reducing thromboxane A2 synthesis. Since both drugs irreversibly affect platelets, their antiplatelet effects persist for the lifespan of the platelet (approximately 7–10 days).

Precautions and Warnings

• Use cautiously in patients with bleeding disorders or history of gastrointestinal ulcers.

• Not recommended in active bleeding conditions.

• Inform your doctor before surgery or dental procedures.

• Use carefully in patients with liver or kidney impairment.

• Avoid concurrent use with other anticoagulants or NSAIDs unless advised by a physician.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Gastric irritation

• Heartburn

• Easy bruising

• Nosebleeds

• Mild abdominal discomfort

Serious side effects such as severe bleeding, black stools, or allergic reactions require immediate medical attention.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Clopid-AS Tablet 75 mg+75 mg provides effective dual antiplatelet therapy for comprehensive cardiovascular protection under proper medical supervision.