Dasaren Tablet 140 mg contains Dasatinib, a targeted anticancer medication classified as a tyrosine kinase inhibitor (TKI). It is primarily used for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Dasatinib works by inhibiting the activity of BCR-ABL tyrosine kinase, a protein responsible for uncontrolled growth of leukemia cells, thereby slowing disease progression and promoting cancer cell death.

This 140 mg formulation is designed for patients requiring a higher dosage, often in cases of advanced or resistant leukemia. Dasaren Tablet offers an effective oral therapy option, allowing patients to take treatment at home under careful medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন.

Composition

Each tablet contains:

• Dasatinib 140 mg

Mechanism of Action

Dasatinib is a BCR-ABL tyrosine kinase inhibitor that binds to the BCR-ABL protein produced by the Philadelphia chromosome mutation. By blocking this protein, Dasatinib prevents abnormal proliferation of leukemia cells and induces apoptosis. It also inhibits other kinases involved in cancer cell growth and survival, making it effective against resistant or advanced forms of leukemia.

Indications

Dasaren Tablet 140 mg is indicated for:

• Chronic, accelerated, or blast phase chronic myeloid leukemia (CML)

• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)

• Patients resistant or intolerant to prior therapy, including Imatinib

• Relapsed or refractory leukemia under oncologist supervision

Dosage and Administration

• The typical dosage is 140 mg orally once daily, or as prescribed by a healthcare professional.

• Take the tablet with water, with or without food.

• Swallow the tablet whole; do not crush or chew.

• Dosage may be adjusted depending on patient response, tolerance, and side effects.

• Regular monitoring of blood counts, liver function, and overall health is essential during treatment.

Precautions

• Use cautiously in patients with liver or kidney impairment.

• Monitor for low blood cell counts (anemia, neutropenia, thrombocytopenia).

• May cause fluid retention, bleeding, or cardiac effects; report swelling, shortness of breath, or unusual bruising immediately.

• Avoid pregnancy during therapy; both male and female patients should use effective contraception.

• Inform your doctor about all other medications to prevent drug interactions.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন.

Possible Side Effects

Common side effects include:

• Low blood cell counts, leading to anemia, infections, or bleeding

• Fatigue, headache, or dizziness

• Nausea, vomiting, or diarrhea

• Fluid retention and swelling of the ankles or around the eyes

• Shortness of breath or cough

Serious side effects such as severe bleeding, heart problems, or liver dysfunction require immediate medical attention.

Storage

• Store below 25°C in a cool, dry place

• Protect from moisture and light

• Keep out of reach of children

Dasaren Tablet 140 mg is an effective and powerful option for patients with Philadelphia chromosome-positive leukemia, especially in advanced or resistant cases. When taken under medical supervision, it helps control cancer progression, improves quality of life, and supports long-term treatment outcomes.