Diasulin Injection 50%+50% combines Regular Insulin Human and Isophane Insulin Human (NPH) in a 50:50 ratio at 40 IU/ml. This premixed insulin is designed to manage both fasting and postprandial blood glucose in patients with type 1 or type 2 diabetes mellitus. The rapid-acting Regular Insulin component controls post-meal glucose spikes, while the intermediate-acting Isophane Insulin ensures sustained basal insulin coverage. This lower-concentration formulation is suitable for patients requiring smaller or more precise insulin doses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regular Insulin Human 50% (rapid-acting)
• Isophane Insulin Human 50% (intermediate-acting)
• Strength: 40 IU/ml

Indications

Diasulin Injection 50%+50% is indicated for:

• Type 1 diabetes mellitus requiring insulin therapy
• Type 2 diabetes mellitus when oral agents alone are insufficient
• Blood glucose management in hospitalized patients or those with fluctuating glucose levels
• Patients needing both rapid and intermediate insulin coverage for optimal glycemic control

Mechanism of Action

• Regular Insulin Human: Rapidly lowers blood glucose by promoting cellular uptake of glucose, inhibiting hepatic glucose production, and supporting protein and lipid metabolism.
• Isophane Insulin Human (NPH): Intermediate-acting insulin slowly releases insulin over 12–16 hours, providing basal glucose control.

Together, they provide a balanced effect for both postprandial and fasting glucose regulation.

Dosage and Administration

• Administer subcutaneously as prescribed by a healthcare professional
• Dose individualized based on blood glucose monitoring, diet, and lifestyle
• Inject before meals for optimal postprandial glucose control
• Rotate injection sites to prevent lipodystrophy
• Do not mix with other insulins unless directed by a physician

Benefits

• Premixed formulation reduces the need for multiple injections daily
• Controls both fasting and post-meal blood glucose effectively
• Supports better overall glycemic stability
• Flexible dosing for patients requiring lower or more precise insulin concentrations
• Convenient for long-term diabetes management

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Injection site reactions such as redness, swelling, or itching
• Mild weight gain

Rare side effects:

• Severe allergic reactions
• Lipodystrophy at repeated injection sites

Seek immediate medical attention for severe hypoglycemia or allergic reactions.

Precautions

• Monitor blood glucose regularly
• Adjust dosage during illness, stress, or changes in diet or activity
• Use cautiously in patients with kidney, liver, or cardiovascular disease
• Keep a source of fast-acting sugar available for hypoglycemia

Contraindications

• Hypersensitivity to insulin or any component of the formulation
• Severe hypoglycemia

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral antidiabetic drugs, corticosteroids, beta-blockers, diuretics, and other medications affecting blood glucose
• Inform your doctor about all medications currently being taken

Storage

• Store refrigerated at 2–8°C; do not freeze
• Protect from direct heat and light
• Once opened, in-use vials can be stored at room temperature (below 30°C) for up to 28 days
• Keep out of reach of children.