Dolonil SR Tablet 100 mg contains Tramadol Hydrochloride, a centrally acting analgesic designed for the management of moderate to moderately severe pain. This sustained-release (SR) formulation provides prolonged pain relief with a once or twice daily dosing regimen, offering convenience and consistent therapeutic effect. Dolonil SR Tablet 100 mg is particularly suitable for patients experiencing chronic pain conditions, including musculoskeletal disorders, post-operative pain, and neuropathic pain, where continuous pain control is essential.

Tramadol combines opioid receptor agonism with inhibition of norepinephrine and serotonin reuptake, providing a dual mechanism that enhances analgesic efficacy while minimizing the risks associated with stronger opioids. The sustained-release technology ensures a steady plasma concentration, reducing the frequency of dosing and improving patient compliance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tramadol Hydrochloride: 100 mg per sustained-release tablet

Indications

Dolonil SR Tablet 100 mg is indicated for:

• Chronic moderate to moderately severe pain

• Post-operative pain requiring extended analgesia

• Musculoskeletal disorders such as arthritis, back pain, or joint pain

• Neuropathic pain, including diabetic neuropathy or post-herpetic neuralgia

• Situations where continuous and prolonged pain control is necessary

• Pain management in patients who need oral sustained-release therapy for convenience and compliance

Mechanism of Action

Tramadol hydrochloride provides analgesia through a dual mechanism:

1. Opioid receptor activation: It binds to μ-opioid receptors in the central nervous system, reducing the perception and transmission of pain.

2. Monoamine reuptake inhibition: Tramadol inhibits serotonin and norepinephrine reuptake, enhancing descending inhibitory pathways in the spinal cord to control pain signals.

This dual action ensures effective relief of both nociceptive and certain types of neuropathic pain, making Dolonil SR Tablet 100 mg a versatile analgesic for chronic and acute pain conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Route: Oral

• Dosage: As prescribed by a registered physician

The usual dose is one sustained-release tablet every 12–24 hours, depending on the severity of pain and patient response. Tablets should be swallowed whole with water and must not be crushed or chewed, as this can destroy the sustained-release mechanism. Dose adjustments may be required in patients with renal or hepatic impairment or elderly patients.

Benefits of Dolonil SR Tablet 100 mg

• Provides prolonged pain relief with reduced dosing frequency

• Effective for chronic and acute pain conditions

• Convenient once or twice daily administration improves compliance

• Dual mechanism enhances efficacy for both nociceptive and neuropathic pain

• Reduces the need for frequent dosing and minimizes peaks and troughs in plasma concentration

Precautions and Warnings

• Use only under medical supervision

• Contraindicated in patients with hypersensitivity to tramadol or other opioids

• Caution in patients with respiratory depression, epilepsy, liver or kidney impairment, or history of substance abuse

• Avoid alcohol and CNS depressants during therapy

• Monitor for side effects such as nausea, dizziness, constipation, or drowsiness

• Not recommended for pediatric patients unless specifically prescribed

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Pharmaceutical Category

Opioid Analgesic (Sustained-Release).