Durogesic Patch 25 mcg/hour contains Fentanyl Citrate, a potent opioid analgesic used for the management of severe chronic pain requiring continuous, long-term opioid therapy. This transdermal patch provides a controlled and sustained release of fentanyl over a period of 72 hours, ensuring consistent pain relief without the need for frequent oral or injectable medications.

Fentanyl is a synthetic opioid that works by acting on the central nervous system to alter the perception and response to pain. The Durogesic Patch 25 mcg/hour is particularly suitable for patients suffering from persistent moderate-to-severe pain due to cancer, chronic musculoskeletal disorders, or other severe pain conditions where non-opioid analgesics are insufficient.

The patch is discreet, convenient, and easy to apply, making it ideal for patients who require continuous analgesia while maintaining daily activities. Its slow, controlled release reduces fluctuations in pain control and improves overall comfort and quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Durogesic Patch 25 mcg/hour is indicated for:

• Management of severe chronic pain that cannot be controlled with non-opioid analgesics

• Pain relief in cancer patients with persistent pain

• Patients who cannot tolerate or swallow oral opioids

• Situations where long-acting, continuous pain control is required

Key Benefits

• Provides continuous 24-hour pain relief for 72 hours

• Reduces the need for frequent oral or injectable opioids

• Convenient and discreet transdermal delivery system

• Helps maintain mobility and daily function in chronic pain patients

• Minimizes fluctuations in pain control with steady plasma levels

Mechanism of Action

Fentanyl Citrate, the active ingredient, is a strong agonist of mu-opioid receptors in the central nervous system. It works by:

• Inhibiting transmission of pain signals in the spinal cord and brain

• Altering perception of pain, increasing pain tolerance

• Producing analgesic effects even in patients with severe, chronic pain

The transdermal route ensures a slow and controlled absorption, maintaining effective blood levels and providing long-lasting analgesia without frequent dosing.

Dosage and Administration

• Each patch delivers 25 mcg/hour over a 72-hour period.

• Apply to clean, dry, hairless skin on the upper torso, upper arm, or chest.

• Rotate application sites to prevent skin irritation.

• Press the patch firmly for 30 seconds to ensure adhesion.

• Replace the patch every 72 hours and remove the old patch before applying a new one.

• Avoid cutting, chewing, or exposing the patch to heat, which can increase fentanyl absorption.

Important: Durogesic Patch 25 mcg/hour is intended for opioid-tolerant patients only. Dose adjustments should be guided by a healthcare professional.

Precautions

• Not for opioid-naïve patients due to risk of life-threatening respiratory depression.

• Use cautiously in patients with respiratory compromise, head injury, hypotension, or liver/kidney impairment.

• Avoid concomitant use with other CNS depressants unless prescribed.

• Keep away from children, pets, and non-prescribed users.

• Seek immediate medical attention in case of severe drowsiness, difficulty breathing, or overdose.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Drowsiness, dizziness, or lightheadedness

• Nausea, vomiting, or constipation

• Dry mouth or sweating

• Rarely, respiratory depression, hypotension, or allergic reactions

Side effects are usually dose-dependent and manageable under medical supervision.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children and pets. Dispose of used patches safely to prevent accidental exposure.