Dysnov Suspension 5 mg/5 ml contains Domperidone Maleate, a dopamine D2 receptor antagonist used to treat nausea, vomiting, and gastrointestinal motility disorders. This oral suspension provides a liquid formulation of domperidone, making it suitable for children, elderly patients, or adults who have difficulty swallowing tablets.

Domperidone works by blocking dopamine receptors in the chemoreceptor trigger zone of the brain, which reduces nausea and vomiting. It also acts peripherally to enhance gastric motility, improving the movement of food through the stomach and intestines. This dual action makes Dysnov Suspension effective for a variety of conditions, including gastroparesis, functional dyspepsia, gastroesophageal reflux disease (GERD), and drug-induced nausea.

Its palatable liquid formulation ensures precise dosing, flexible administration, and rapid onset of action, which is particularly useful in pediatric and geriatric patients. Dysnov Suspension is well-tolerated and generally free from central nervous system side effects, as it does not readily cross the blood-brain barrier.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Dysnov Suspension 5 mg/5 ml is indicated for:

• Nausea and vomiting due to gastrointestinal disorders, drugs, or systemic illness

• Gastroparesis and delayed gastric emptying, particularly in diabetic patients

• Functional dyspepsia, relieving bloating, early satiety, and upper abdominal discomfort

• Gastroesophageal reflux disease (GERD), to improve gastric emptying and reduce reflux

• Supportive treatment in post-operative nausea and chemotherapy- or radiotherapy-induced nausea

Key Benefits

• Rapidly relieves nausea and vomiting

• Enhances gastric emptying and intestinal motility

• Improves digestion and relief from bloating in functional dyspepsia

• Oral suspension provides flexible dosing, especially for children and elderly patients

• Minimal central nervous system side effects due to limited blood-brain barrier penetration

Mechanism of Action

Domperidone Maleate is a selective dopamine D2 receptor antagonist that acts through:

1. Central antiemetic action: By blocking dopamine receptors in the chemoreceptor trigger zone, it suppresses the vomiting reflex and reduces nausea.

2. Peripheral prokinetic action: By stimulating the gastrointestinal tract muscles, it accelerates gastric emptying, reduces stomach distension, and alleviates bloating or discomfort.

This combination of actions ensures effective management of both symptoms and underlying motility issues.

Dosage and Administration

• Children: Dose is typically 0.25–0.5 mg/kg per dose, 3 times daily, 15–30 minutes before meals, as advised by a physician

• Adults: Usually 10–20 mg, 3 times daily, before meals

• Shake the suspension well before use and measure the dose with an accurate measuring device

• Swallow the measured dose directly; do not mix with other liquids unless instructed by a doctor

• Follow the prescribed duration and dosage strictly for best results

Precautions

• Use with caution in patients with heart rhythm disorders, liver impairment, or gastrointestinal bleeding

• Avoid use with medications that may prolong the QT interval or interact with dopamine pathways

• Not recommended during pregnancy or lactation without medical supervision

• Seek medical advice if symptoms persist or worsen during treatment

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Dysnov Suspension is generally well tolerated. Common side effects may include:

• Mild abdominal discomfort or diarrhea

• Dry mouth

• Headache or dizziness

• Rarely, cardiac arrhythmias, particularly in patients with pre-existing heart conditions

Most side effects are mild and transient, resolving without the need to discontinue therapy.

Storage

Store below 30°C in a cool, dry place, protected from direct sunlight and moisture. Keep out of reach of children.