Fluconal Suspension 50 mg/5 ml contains Fluconazole, a potent triazole antifungal agent designed for use in children and adults who may have difficulty swallowing tablets. Fluconazole works by inhibiting fungal cytochrome P450 enzyme 14α-demethylase, which is essential for the synthesis of ergosterol, a critical component of the fungal cell membrane. Disruption of ergosterol production weakens the fungal cell membrane, leading to fungal cell death or inhibition of growth, depending on the severity of infection.

Fluconal Suspension is widely used for the treatment of oropharyngeal candidiasis, esophageal candidiasis, systemic fungal infections, and vaginal yeast infections. The oral suspension provides accurate dosing and excellent absorption, making it particularly suitable for pediatric patients and adults requiring flexible dosing. Its palatable formulation enhances compliance and ensures therapeutic efficacy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Fluconal Suspension 50 mg/5 ml is indicated for the treatment and prevention of:

• Oropharyngeal and esophageal candidiasis

• Systemic fungal infections caused by susceptible fungi

• Vaginal candidiasis (yeast infections)

• Cryptococcal meningitis

• Prophylaxis of fungal infections in immunocompromised patients

The suspension should be used when a fungal infection is confirmed or strongly suspected to avoid unnecessary exposure and resistance development.

Mechanism of Action

• Inhibition of ergosterol synthesis: Fluconazole selectively inhibits 14α-demethylase, a key enzyme in fungal cell membrane synthesis.

• Fungistatic or fungicidal effect: Reduced ergosterol levels weaken the cell membrane, preventing fungal growth or causing cell death.

• Broad-spectrum activity: Effective against Candida species such as Candida albicans, Candida glabrata, and Candida tropicalis, as well as Cryptococcus neoformans.

Dosage and Administration

Dosage should be individualized based on the patient’s age, weight, and type of infection:

• Children: 3–6 mg/kg/day orally, once daily, depending on the infection severity

• Adults: Dose varies from 50–200 mg daily, adjusted according to infection type

• Administration: Shake the bottle well before use to ensure uniform suspension

• Use the provided oral syringe or measuring cup for accurate dosing

• Can be taken with or without food

• Complete the full course of therapy even if symptoms improve early to prevent recurrence and resistance

Benefits and Features

• Provides effective treatment for a wide range of superficial and systemic fungal infections

• Convenient oral suspension for infants, children, and adults with swallowing difficulties

• Rapid systemic absorption ensures therapeutic efficacy

• Well-tolerated with minimal systemic side effects

• Supports prophylactic use in high-risk or immunocompromised patients

Side Effects

Fluconal Suspension is generally well tolerated. Some patients may experience:

• Gastrointestinal symptoms: nausea, vomiting, diarrhea, abdominal discomfort

• Headache or dizziness

• Mild skin rash or itching

• Rarely, liver enzyme elevation or hepatotoxicity

• Severe allergic reactions are uncommon but require immediate medical attention

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with hepatic or renal impairment

• Monitor liver function during prolonged therapy

• Avoid in patients with known fluconazole hypersensitivity

• May interact with medications metabolized by CYP450 enzymes, including anticoagulants, anti-arrhythmic drugs, and certain statins

• Not recommended during pregnancy unless prescribed by a healthcare professional

• Keep out of reach of children

Storage Conditions

Store Fluconal Suspension 50 mg/5 ml in a cool, dry place below 30°C, protected from light and moisture. Keep the bottle tightly closed and shake well before use.

Fluconal Suspension 50 mg/5 ml is a safe and effective antifungal solution for pediatric and adult patients, providing broad-spectrum fungal coverage, accurate dosing, and convenient oral administration.