Folinex Injection contains Folinic Acid (Leucovorin) 10 mg/ml, a biologically active form of folic acid used in medical and oncology settings. It plays an important role in rescuing normal cells from the toxic effects of certain chemotherapy drugs and is also used to enhance the effectiveness of specific anticancer treatments.

Unlike folic acid, folinic acid does not require metabolic activation, allowing it to act quickly in the body.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Folinex Injection is indicated for:

• Rescue therapy after high-dose methotrexate chemotherapy
• Reduction of toxicity from antifolate drugs (e.g., methotrexate overdose)
• Combination therapy with 5-fluorouracil (5-FU) in colorectal cancer
• Treatment of folate deficiency anemia (when oral therapy is not suitable)
• Supportive care in oncology chemotherapy regimens

Mechanism of Action

Folinic Acid works through multiple mechanisms:

• Bypasses dihydrofolate reductase inhibition caused by methotrexate
• Restores normal folate-dependent metabolic processes in healthy cells
• Reduces toxicity of antifolate chemotherapy drugs
• Enhances binding of 5-FU metabolites to thymidylate synthase (in cancer therapy)
• Protects normal tissues while supporting anticancer efficacy

Dosage & Administration

• Administered via intravenous or intramuscular injection
• Dose depends on indication and chemotherapy protocol
• Used according to oncology or emergency treatment guidelines
• Must be administered under medical supervision
• Timing is critical when used with methotrexate or 5-FU
• Regular monitoring is required during therapy

Side Effects

Folinex Injection is generally well tolerated, but may cause:

• Nausea
• Vomiting
• Allergic reactions (rare)
• Fever or flushing
• Injection site discomfort
• Rare hypersensitivity reactions

Serious reactions are uncommon when used correctly.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under specialist supervision
• Do not use without correct timing in methotrexate therapy
• Caution in patients with hypersensitivity to folates
• Monitor blood counts during chemotherapy protocols
• Inform physician about all ongoing medications
• Use during pregnancy only if clearly needed

Storage

• Store below 25°C in a cool and dry place
• Protect from light
• Do not freeze
• Keep in original packaging
• Keep out of reach of children.