Glifo-M XR Tablet 5 mg+1000 mg is a combination oral antidiabetic medicine formulated with Empagliflozin 5 mg and Metformin Hydrochloride 1000 mg in an extended-release (XR) form. It is indicated for the management of type 2 diabetes mellitus in adults who require combination therapy for better glycemic control. This fixed-dose combination works alongside proper diet and regular exercise to help maintain stable blood glucose levels.

By combining two well-established antidiabetic agents with complementary mechanisms of action, Glifo-M XR offers comprehensive and sustained glucose control throughout the day.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each extended-release tablet contains:

• Empagliflozin 5 mg

• Metformin Hydrochloride 1000 mg (Extended Release)

Mechanism of Action

Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It reduces blood glucose by blocking glucose reabsorption in the kidneys, leading to increased excretion of glucose in urine. This mechanism works independently of insulin and may also assist in modest weight reduction.

Metformin Hydrochloride, a biguanide, primarily decreases hepatic glucose production and improves insulin sensitivity. It also reduces intestinal absorption of glucose and enhances peripheral glucose uptake. The extended-release formulation allows gradual release of Metformin, ensuring prolonged therapeutic action and improved gastrointestinal tolerability.

The combination of these two agents addresses multiple aspects of glucose regulation, helping patients achieve improved overall glycemic control.

Indications

Glifo-M XR Tablet 5 mg+1000 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Patients inadequately controlled with Metformin or Empagliflozin alone

• Individuals requiring dual therapy to achieve target blood glucose levels

• Use as part of a comprehensive diabetes management plan including lifestyle modification

Benefits

• Dual mechanism for effective blood sugar control

• Helps reduce fasting and postprandial glucose levels

• Extended-release formulation enhances tolerability

• May support weight management and metabolic balance

• Convenient dosing to improve treatment adherence

Dosage and Administration

The dosage should be individualized and prescribed by a qualified healthcare professional. It is typically taken once daily with meals to minimize gastrointestinal discomfort. The tablet should be swallowed whole with water and should not be crushed, broken, or chewed.

Precautions

• Not recommended for patients with severe renal impairment

• Renal function should be assessed before and during treatment

• Rare risk of lactic acidosis associated with Metformin

• Ensure adequate hydration to reduce the risk of dehydration

• Inform your physician about any liver, kidney, or cardiovascular conditions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Some commonly reported side effects include:

• Nausea or abdominal discomfort

• Increased urination

• Urinary tract infections

• Genital fungal infections

• Headache or dizziness

If any serious or persistent side effects occur, seek medical attention promptly.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Glifo-M XR Tablet 5 mg+1000 mg provides an effective and well-tolerated combination therapy option for adults managing type 2 diabetes under proper medical supervision.