Hepagurd 3 gm is a therapeutic preparation designed to support liver function and manage complications associated with liver diseases. It contains L-Ornithine and L-Aspartate, two endogenous amino acids that play a crucial role in detoxification, ammonia metabolism, and liver cell regeneration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Digestive Enzyme

Indications

Hepagurd 3 gm is indicated for the treatment and management of:

• Hepatic Encephalopathy

• Acute Liver Failure

• Hyperammonemia caused by acute or chronic hepatitis

• Fatty Liver Disease

• Alcoholic Liver Damage

• As an adjunct during therapy with hepatotoxic drugs

• Liver Cirrhosis

• Post-hepatitis convalescence

Pharmacology

Hepagurd 3 gm is a stable combination of L-Ornithine and L-Aspartate:

• L-Ornithine: Acts as a substrate in the urea cycle, converting toxic ammonia into non-toxic urea, which is eliminated by the kidneys, reducing hyperammonemia.

• L-Aspartate: An essential component of the citric acid cycle, which generates energy (ATP) and supports regeneration of damaged liver cells.

This dual mechanism improves detoxification, liver metabolism, and overall liver function, making it effective in conditions associated with elevated ammonia levels.

Dosage & Administration

Oral (Sachet/Granules):

• 1–2 sachets dissolved in a glass of water or juice

• Taken 3 times daily during or after meals

Intravenous (Infusion Concentrate):

• Up to 20 gm (4 ampoules daily)

• In severe cases (pre-coma or coma), up to 8 ampoules in 24 hours depending on severity

• Can be added to conventional IV fluids like 0.9% Sodium Chloride, 5% Dextrose, or Ringer's lactate

• Normal dilution: 1 ampoule per 100 ml fluid

• Maximum infusion rate: 5 gm/hour

Interactions

• No known drug interactions have been reported

Side Effects

• Very rare: nausea and vomiting

• Generally well-tolerated, transient, and do not require discontinuation

Precautions & Warnings

• Regular monitoring of serum and urinary urea levels is recommended

• Avoid use in pregnancy and lactation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Conditions

• Store in a cool, dry place

• Protect from light

• Keep out of reach of children

Mode of Action

1. L-Ornithine: Supports the urea cycle, converting ammonia into urea, reducing blood ammonia levels.

2. L-Aspartate: Enters the citric acid cycle, producing ATP and helping in regeneration of liver cells.

3. Overall: Helps the liver carry out normal detoxification processes efficiently and promotes recovery in liver diseases.