L-DOX Injection 20 mg/10 ml contains Doxorubicin Hydrochloride in a liposomal formulation, an advanced form of a well-known anthracycline anticancer agent. This liposomal delivery system enhances drug targeting to tumor tissues while reducing toxicity to healthy cells, particularly the heart. It is widely used in the treatment of various cancers, offering improved tolerability compared to conventional doxorubicin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Doxorubicin Hydrochloride Liposome equivalent to 20 mg per 10 ml

Mechanism of Action

Doxorubicin works by intercalating into DNA and inhibiting the enzyme topoisomerase II, which is essential for DNA replication and repair. This leads to the disruption of cancer cell growth and eventual cell death. The liposomal encapsulation allows for prolonged circulation in the bloodstream and preferential accumulation in tumor tissues, improving therapeutic efficacy while minimizing systemic toxicity.

Indications

L-DOX Injection is indicated for the treatment of:

• Breast cancer
• Ovarian cancer
• Multiple myeloma
• Kaposi’s sarcoma associated with AIDS
• Other solid tumors as directed by an oncologist

Dosage and Administration

• Administered intravenously under the supervision of a qualified healthcare professional.
• Dosage depends on the type of cancer, body surface area, and patient condition.
• Infusion rates and treatment cycles are determined by the treating physician.
• Pre-medication may be required to reduce infusion-related reactions.

Benefits

• Targeted drug delivery through liposomal technology
• Reduced risk of cardiotoxicity compared to conventional doxorubicin
• Enhanced accumulation in tumor tissues
• Improved tolerability and safety profile
• Effective against a wide range of cancers

Side Effects

Common side effects may include:

• Nausea and vomiting
• Fatigue
• Hair loss (alopecia)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Low blood cell counts (anemia, neutropenia)

Serious side effects:

• Cardiotoxicity (though reduced compared to standard doxorubicin)
• Severe infusion reactions
• Liver function abnormalities
• Secondary malignancies (rare)

Immediate medical attention is required if severe adverse effects occur.

Precautions and Warnings

• Cardiac function should be monitored before and during treatment.
• Use with caution in patients with liver impairment.
• Regular blood tests are necessary to monitor blood counts.
• Avoid use during pregnancy due to potential harm to the fetus.
• Patients should avoid live vaccines during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

L-DOX Injection may interact with:

• Other chemotherapy agents
• Cardiotoxic drugs
• Immunosuppressive medications

Inform the healthcare provider about all ongoing treatments before starting therapy.

Storage

• Store at 2°C to 8°C (refrigerated)
• Do not freeze
• Protect from light
• Keep out of reach of children.