Lacomax 100 mg contains Lacosamide, an antiepileptic drug used to manage partial-onset seizures in adults and pediatric patients aged 4 years and above. It is particularly effective in reducing the frequency of focal seizures with or without secondary generalization. Lacosamide is recognized for its novel mechanism of action and favorable safety profile, making it a preferred option for patients with refractory epilepsy or those who require adjunctive therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Antiepileptic / Anticonvulsant

Pharmacology

Lacosamide exerts its antiepileptic effects through selective enhancement of slow inactivation of voltage-gated sodium channels, stabilizing hyperexcitable neuronal membranes and inhibiting repetitive neuronal firing. Unlike traditional sodium channel blockers, Lacosamide does not significantly affect the fast inactivation process, which contributes to its efficacy and tolerability.

Pharmacokinetic properties of Lacosamide include:

• Rapid and almost complete oral absorption, with peak plasma concentrations reached within 1–4 hours

• Bioavailability close to 100%, unaffected by food

• Low protein binding (less than 15%), minimizing drug-drug interactions

• Metabolism occurs primarily via CYP2C19 and minor CYP-independent pathways

• Elimination half-life is approximately 13 hours, allowing for twice-daily dosing

• Excretion is mainly through the kidneys, with around 40% of the drug excreted unchanged

Indications

Lacomax 100 mg is indicated for:

• Adjunctive therapy in adults and children (≥4 years) with partial-onset seizures

• Monotherapy for partial-onset seizures in adults with newly diagnosed epilepsy

Dosage and Administration

Adults:

• Initial dose: 50 mg twice daily

• Titration: Increase by 100 mg/day weekly up to a maintenance dose of 200–400 mg/day (divided into two doses)

• Maximum recommended dose: 400 mg/day

Pediatric Patients (≥4 years):

• Initial dose: 1–2 mg/kg twice daily

• Titration: Gradually increase by 1–2 mg/kg every week

• Maximum recommended dose: 12 mg/kg/day or 400 mg/day, whichever is lower

Administration Notes:

• Can be taken with or without food

• Tablets should be swallowed whole with water

• Doses should be adjusted gradually to minimize the risk of adverse effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Lacosamide or any excipients in the formulation

• Caution is advised in patients with severe cardiac conditions, including conduction abnormalities

Side Effects

Lacosamide is generally well tolerated. Common adverse reactions include:

• Dizziness, headache, and fatigue

• Nausea and vomiting

• Diplopia or blurred vision

• Rare cardiac effects such as PR interval prolongation, arrhythmias, or syncope

• Ataxia and tremor in some patients

Precautions and Warnings

• Monitor ECG in patients with pre-existing conduction abnormalities or those on other drugs affecting cardiac conduction

• Dose adjustments may be necessary in patients with renal or hepatic impairment

• Caution when used in combination with other central nervous system depressants

Pregnancy and Lactation

• Lacosamide should be used during pregnancy only if clearly needed

• Excretion into breast milk has been reported; nursing mothers should exercise caution

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.