Lemodip Tablet 1.25 mg contains Levamlodipine Maleate, the pharmacologically active S-enantiomer of amlodipine. It is a long-acting calcium channel blocker used primarily for the management of hypertension and related cardiovascular conditions. Compared with conventional amlodipine, levamlodipine provides effective blood pressure control at a lower dose, with improved tolerability and a reduced incidence of dose-related adverse effects such as peripheral edema.

Lemodip is suitable for patients who require gentle yet sustained antihypertensive therapy, including elderly patients and those sensitive to standard doses of calcium channel blockers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium channel blockers
Antihypertensive agents

Indications

Lemodip Tablet 1.25 mg is indicated for the treatment of:

• Essential hypertension (mild to moderate)

• Hypertension in patients requiring low-dose therapy

• Cardiovascular risk reduction through effective blood pressure control

It may be used as monotherapy or in combination with other antihypertensive agents such as ACE inhibitors, angiotensin receptor blockers, or diuretics.

Pharmacology

Levamlodipine selectively inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle by blocking L-type calcium channels. This inhibition leads to relaxation of vascular smooth muscle, resulting in peripheral arterial vasodilation and a subsequent reduction in blood pressure.

As the S-enantiomer of amlodipine, levamlodipine has higher receptor affinity and greater pharmacological potency, allowing effective antihypertensive action at lower doses. It has minimal effects on heart rate and myocardial contractility, making it suitable for long-term use in a wide range of patients.

Levamlodipine is slowly absorbed following oral administration and provides a gradual onset and sustained duration of action, supporting once-daily dosing.

Dosage & Administration

• Recommended starting dose: 1.25 mg once daily

• The dose may be adjusted based on clinical response and blood pressure control

Lemodip Tablet may be taken with or without food and should be swallowed whole with water. Dose titration should be performed cautiously, particularly in elderly patients or those with hepatic impairment.

Drug Interactions

• Antihypertensive agents: Additive blood pressure-lowering effect may occur

• CYP3A4 inhibitors may increase plasma concentrations of levamlodipine

• CYP3A4 inducers may reduce therapeutic efficacy

Caution is advised when co-administered with other drugs affecting blood pressure or cardiovascular function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to levamlodipine, amlodipine, or any excipients

• Severe hypotension

• Cardiogenic shock

Side Effects

Lemodip Tablet 1.25 mg is generally well tolerated. Possible side effects include:

• Headache

• Dizziness

• Flushing

• Peripheral edema

• Fatigue

These effects are usually mild and less frequent compared with conventional amlodipine therapy.

Precautions & Warnings

• Use with caution in patients with severe hepatic impairment

• Monitor blood pressure regularly during treatment

• Caution in patients with heart failure or aortic stenosis

• Sudden discontinuation should be avoided unless clinically indicated

Pregnancy & Lactation

• Pregnancy: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus

• Lactation: It is unknown whether levamlodipine is excreted in human milk. Caution is advised when administered to breastfeeding women

Storage Conditions

• Store below 30°C

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Lemodip lowers blood pressure by selectively blocking L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced peripheral vascular resistance. The enhanced selectivity of levamlodipine allows effective blood pressure control with improved safety and tolerability.