Level-K Powder 150 gm/sachet is a pharmaceutical preparation primarily used to manage hyperkalemia, a condition characterized by elevated levels of potassium in the blood. By helping to reduce excess potassium, Level-K plays a critical role in maintaining proper electrolyte balance and preventing potentially life-threatening cardiac complications associated with hyperkalemia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Potassium-binding resin

• Electrolyte regulator

Indications

Level-K Powder 150 gm/sachet is indicated for:

• Hyperkalemia: Elevated serum potassium levels due to renal failure, acute kidney injury, or other causes.

• Prevention of potassium overload in patients receiving potassium supplements or potassium-sparing medications.

• Adjunct treatment in cases where dietary modification alone is insufficient to control potassium levels.

Pharmacology

The active ingredient, Sodium Polystyrene Sulfonate (SPS), is a cation-exchange resin. It works by exchanging sodium ions for potassium ions in the intestine, primarily in the large intestine. The resin binds potassium in the gastrointestinal tract and facilitates its fecal excretion, thereby reducing serum potassium levels.

• SPS does not get absorbed systemically; its action is entirely localized within the gut.

• The onset of potassium-lowering effect typically occurs within a few hours to a day depending on the severity of hyperkalemia and patient-specific factors.

• While effective, SPS should be used alongside other measures such as dietary potassium restriction and monitoring of renal function to ensure safe potassium management.

Dosage and Administration

Adults:

• The usual oral dose is 15–60 g per day, administered in divided doses depending on the severity of hyperkalemia and patient response.

• The powder should be mixed with water or syrup to create a suspension before administration to ensure even dispersion.

Children:

• Pediatric dosing should be carefully adjusted according to body weight and clinical condition. Consultation with a pediatric nephrologist is recommended.

Administration tips:

• Always mix Level-K powder thoroughly before administration.

• Administer with or after meals to reduce gastrointestinal discomfort.

• Monitor serum potassium levels regularly to guide dosage adjustments.

Interaction

• Level-K may interfere with the absorption of other oral medications, including digoxin, lithium, and certain antibiotics.

• To avoid interactions, other medications should be taken at least 2 hours before or after Level-K administration.

Contraindications

• Hypersensitivity to Sodium Polystyrene Sulfonate or any component of the formulation

• Severe constipation or intestinal obstruction

• Recent gastrointestinal surgery, especially involving the colon

• Patients with significant sodium restriction may require caution due to the sodium content of the preparation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Level-K is generally well tolerated but may cause:

• Gastrointestinal effects such as nausea, vomiting, constipation, or diarrhea

• Abdominal discomfort or bloating

• Rarely, intestinal necrosis, particularly in patients with compromised bowel function

• Electrolyte imbalances, including hypokalemia if used excessively

Pregnancy and Lactation

• Safety in pregnancy and lactation has not been fully established.

• Use only if the potential benefit justifies the potential risk.

Precautions and Warnings

• Regular monitoring of serum potassium, sodium, and calcium is essential during therapy.

• Avoid prolonged or excessive use to prevent hypokalemia and other electrolyte disturbances.

• Use with caution in patients with heart failure or edema due to sodium load.

Storage Conditions

• Store at room temperature (below 30°C) in a dry place

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Sodium Polystyrene Sulfonate acts as a potassium-binding resin that exchanges sodium ions for potassium ions in the colon. This facilitates the removal of potassium through fecal excretion, helping to correct hyperkalemia and maintain electrolyte homeostasis.

Drug Classes

• Potassium binder

• Electrolyte modifier

Level-K Powder 150 gm/sachet is an effective and widely used therapy for managing hyperkalemia, offering a crucial tool in electrolyte control for patients with renal or metabolic disorders.