Levofed DS Injection 4 mg/4 ml contains Norepinephrine Tartrate, a potent vasopressor used in emergency and intensive care medicine. It is indicated for the rapid management of severe hypotension and shock conditions where immediate blood pressure support is essential to maintain vital organ perfusion. The “DS” strength provides a higher concentration formulation for controlled critical care use under strict medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Norepinephrine Tartrate equivalent to Norepinephrine 4 mg per 4 ml

Mechanism of Action

Norepinephrine is an endogenous catecholamine that primarily stimulates alpha-1 adrenergic receptors, causing strong vasoconstriction of peripheral blood vessels. It also stimulates beta-1 receptors in the heart, contributing to mild increases in cardiac output. These combined actions result in a significant rise in blood pressure and improved circulation to vital organs in shock states.

Indications

Levofed DS Injection is indicated for:

• Severe acute hypotension
• Septic shock
• Cardiogenic shock
• Neurogenic shock
• Blood pressure support during critical care and surgical emergencies

Dosage and Administration

• Administered as a continuous intravenous infusion only
• Dosage is individualized and carefully titrated based on patient response
• Preferably given via central venous line to reduce risk of tissue damage
• Continuous monitoring of blood pressure, heart rate, and organ perfusion is mandatory
• To be used only in ICU, emergency, or closely monitored hospital settings

Benefits

• Rapid and effective restoration of blood pressure in critical conditions
• Helps maintain adequate perfusion of vital organs
• Essential drug in management of shock and life-threatening hypotension
• Provides dose flexibility in intensive care settings
• Improves survival outcomes when used appropriately in ICU care

Side Effects

Common side effects may include:

• Headache
• Anxiety or agitation
• Slow or irregular heartbeat
• Elevated blood pressure

Serious side effects:

• Severe hypertension
• Cardiac arrhythmias
• Peripheral ischemia (reduced blood flow to extremities)
• Tissue necrosis if drug leaks outside the vein (extravasation)

Immediate medical attention is required if serious reactions occur.

Precautions and Warnings

• For hospital and ICU use only under expert supervision
• Continuous cardiovascular monitoring is essential
• Avoid extravasation to prevent local tissue injury
• Correct hypovolemia prior to initiation when possible
• Use cautiously in patients with heart disease or peripheral vascular disease

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Levofed DS Injection may interact with:

• MAO inhibitors
• Tricyclic antidepressants
• Other vasopressors or sympathomimetics
• Beta-blockers

Always inform the healthcare team about all ongoing medications.

Storage

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.