Loncil Tablet is an oral anticancer medication that combines Trifluridine and Tipiracil, specifically formulated for the treatment of certain types of advanced cancers. This combination works synergistically to inhibit cancer cell growth and prolong patient survival, particularly in cases where other treatments have not been effective. It is commonly prescribed for metastatic colorectal cancer and may also be used in other resistant malignancies as directed by an oncologist.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Trifluridine 15 mg
• Tipiracil 6.14 mg

Mechanism of Action

Loncil Tablet works through a dual-action mechanism:

• Trifluridine is a nucleoside analog that gets incorporated into the DNA of cancer cells, interfering with DNA function and preventing cell replication.
• Tipiracil inhibits the enzyme thymidine phosphorylase, which helps maintain adequate levels of trifluridine in the body by preventing its rapid breakdown.

This combination enhances the effectiveness of the drug against cancer cells.

Indications

Loncil Tablet is indicated for:

• Metastatic colorectal cancer (CRC) in patients who have previously received standard therapies
• Advanced or refractory cancers as advised by a healthcare professional

Dosage and Administration

• The dosage is determined by the physician based on body surface area, medical condition, and response to treatment.
• It is usually taken orally, twice daily after meals.
• Tablets should be swallowed whole with water and not crushed or chewed.
• Follow the prescribed treatment cycle strictly for optimal results.

Benefits

• Helps slow the progression of advanced cancers
• Improves survival outcomes in treatment-resistant cases
• Oral administration offers convenience compared to injectable therapies

Possible Side Effects

Common side effects may include:

• Nausea and vomiting
• Fatigue or weakness
• Loss of appetite
• Diarrhea
• Decreased blood cell counts (anemia, neutropenia)

Serious side effects should be reported immediately, including signs of infection, unusual bleeding, or severe weakness.

Precautions

• Regular blood tests are required to monitor blood cell counts.
• Use with caution in patients with liver or kidney impairment.
• Not recommended during pregnancy or breastfeeding.
• Effective contraception should be used during treatment and for a period after discontinuation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Loncil Tablet may interact with:

• Other chemotherapy agents
• Immunosuppressive drugs
• Certain antiviral or antifungal medications

Always inform your doctor about all medications and supplements you are taking.

Storage

• Store below 30°C in a dry place
• Keep away from light and moisture
• Keep out of reach of children.