Loncil Tablet 20 mg + 8.19 mg is an oral chemotherapy medication that combines Trifluridine and Tipiracil, designed for the treatment of advanced or metastatic cancers, particularly colorectal cancer. This formulation is typically prescribed for patients who have already undergone standard cancer therapies without sufficient response. The dual-drug combination enhances anticancer activity and helps improve survival outcomes in resistant cases.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Trifluridine 20 mg
• Tipiracil 8.19 mg

Mechanism of Action

Loncil Tablet works through a complementary mechanism:

• Trifluridine acts as an antimetabolite that incorporates into cancer cell DNA, disrupting DNA synthesis and inhibiting tumor cell proliferation.
• Tipiracil prevents the rapid degradation of trifluridine by inhibiting thymidine phosphorylase, thereby increasing its availability and therapeutic effect.

Together, they ensure sustained anticancer activity.

Indications

Loncil Tablet is indicated for:

• Metastatic colorectal cancer (CRC) in patients previously treated with standard therapies
• Advanced cancers that are resistant to conventional treatment, as advised by a physician

Dosage and Administration

• Dosage is individualized based on body surface area, overall health, and clinical response.
• Usually taken orally twice daily after meals.
• Swallow the tablet whole with water; do not crush or chew.
• Follow the treatment schedule prescribed by the oncologist carefully.

Benefits

• Slows progression of advanced cancer
• Provides a treatment option for therapy-resistant cases
• Convenient oral administration compared to intravenous chemotherapy

Possible Side Effects

Common side effects include:

• Nausea and vomiting
• Fatigue
• Diarrhea
• Loss of appetite
• Bone marrow suppression (e.g., neutropenia, anemia)

Seek medical attention if severe symptoms such as infection, fever, or unusual bleeding occur.

Precautions

• Regular monitoring of blood counts is essential during treatment.
• Use cautiously in patients with kidney or liver impairment.
• Avoid use during pregnancy and breastfeeding.
• Effective contraception is recommended during and after treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Loncil Tablet may interact with:

• Other anticancer drugs
• Immunosuppressants
• Certain antifungal and antiviral medications

Always inform your healthcare provider about all medicines you are taking.

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.