Losardil 25/12.5 Tablet is a combination antihypertensive medication containing Losartan Potassium 25 mg and Hydrochlorothiazide 12.5 mg. This formulation is designed for adults with mild to moderate hypertension who require a balanced approach to blood pressure control that combines the benefits of an angiotensin II receptor blocker (ARB) and a thiazide diuretic.

Losartan works by relaxing blood vessels through inhibition of angiotensin II, a hormone responsible for vasoconstriction, while Hydrochlorothiazide reduces blood volume by increasing urinary excretion of sodium and water. This combination provides synergistic antihypertensive effects, helping to achieve target blood pressure more effectively than monotherapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

Losardil 25/12.5 Tablet exerts its effects through two complementary mechanisms:

• Losartan (25 mg):

  • Blocks angiotensin II at AT1 receptors, preventing blood vessel constriction.

  • Promotes vasodilation and reduces systemic vascular resistance, lowering blood pressure.

  • Protects the kidneys by reducing intraglomerular pressure, especially in diabetic patients with proteinuria.

• Hydrochlorothiazide (12.5 mg):

  • Acts as a thiazide diuretic by increasing excretion of sodium and water from the kidneys.

  • Reduces blood volume, contributing to decreased blood pressure.

  • Helps manage fluid retention associated with hypertension.

The combination ensures more consistent and enhanced blood pressure reduction, particularly beneficial for patients not fully controlled on lower-dose monotherapy.

Indications

Losardil 25/12.5 Tablet is indicated for:

• Essential hypertension: For adults needing mild to moderate blood pressure control.

• Combination therapy: For patients whose blood pressure is not adequately controlled with a single antihypertensive agent.

• Cardiovascular risk reduction: Helps lower the risk of stroke, heart attack, and heart failure.

• Renal protection in diabetes: Assists in reducing proteinuria and slowing progression of kidney damage in type 2 diabetes patients.

It is not suitable for patients who are pregnant, breastfeeding, or have severe kidney or liver disease, or those with hypersensitivity to Losartan or Hydrochlorothiazide.

Dosage and Administration

• The recommended adult dose is 1 tablet once daily, taken orally with or without food.

• Swallow the tablet whole with water; do not crush or chew.

• Blood pressure should be monitored regularly to assess treatment response.

• Dosage adjustments may be required in patients with renal or hepatic impairment.

• Lifestyle modifications, such as dietary salt restriction, exercise, and weight management, should be maintained for optimal results.

Precautions

• Avoid use during pregnancy, as ARBs may cause fetal harm.

• Monitor kidney function, electrolytes, and blood pressure regularly, particularly during initiation of therapy.

• Inform your doctor of all medications being taken, including potassium supplements, other diuretics, or NSAIDs.

• Use caution in patients with low blood pressure, dehydration, or electrolyte imbalance.

• Elderly patients may require closer monitoring due to increased sensitivity to antihypertensive therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Dizziness or lightheadedness

• Fatigue or headache

• Gastrointestinal disturbances, such as nausea or abdominal discomfort

• Increased urination due to the diuretic effect

Rare but serious side effects include:

• Hyperkalemia (high potassium levels)

• Hypotension (excessive reduction in blood pressure)

• Impaired kidney function

• Severe allergic reactions, including rash, swelling, or difficulty breathing

Seek immediate medical attention if severe or persistent symptoms occur.

Storage

Store below 30°C in a dry, cool place, protected from sunlight and moisture. Keep out of reach of children.

Losardil 25/12.5 Tablet provides effective blood pressure control, combining Losartan and Hydrochlorothiazide to support cardiovascular health, reduce kidney strain, and minimize the risk of hypertension-related complications.