Lubistone 24 mcg is a highly effective, locally-acting chloride-channel activator used for the management of chronic constipation-related conditions. It is indicated for Irritable Bowel Syndrome with Constipation (IBS-C), Chronic Idiopathic Constipation (CIC), and Opioid-Induced Constipation (OIC) in adults with chronic non-cancer pain. By enhancing intestinal fluid secretion and motility, Lubistone 24 mcg facilitates smooth bowel movements and provides symptomatic relief from constipation-related discomfort.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Other laxative preparations

Pharmacology

Lubistone 24 mcg selectively activates ClC-2 chloride channels on the apical membrane of the intestinal epithelium. This action triggers chloride ion efflux into the intestinal lumen, followed by sodium ions through a paracellular pathway to maintain electrical neutrality. Water follows these ions, increasing intestinal fluid secretion. The result is enhanced intestinal motility, improved stool passage, and relief of constipation symptoms.

In addition to its secretory effect, Lubistone may help restore mucosal barrier function by supporting tight junction proteins in the intestinal lining. This targeted luminal activity ensures minimal systemic absorption and reduced risk of systemic side effects.

Indications

Lubistone 24 mcg is indicated for:

• Irritable Bowel Syndrome with Constipation (IBS-C) in adults

• Chronic Idiopathic Constipation (CIC) in adults

• Opioid-Induced Constipation (OIC) in adult patients with chronic, non-cancer pain

Dosage and Administration

• IBS-C: 8 mcg orally twice daily with food and water. For severe hepatic impairment, start with 8 mcg once daily, increasing to twice daily if tolerated.

• CIC & OIC: 24 mcg orally twice daily with food and water. In moderate hepatic impairment, start with 16 mcg twice daily; in severe impairment, start with 8 mcg twice daily.

Lubistone should be taken with meals to improve tolerability and reduce nausea.

Drug Interactions

• Diphenylheptane opioids may reduce Lubistone’s efficacy in a dose-dependent manner.

Contraindications

• Known or suspected mechanical gastrointestinal obstruction

Side Effects

• Diarrhea

• Abdominal bloating or fullness

• Nausea

• Stomach pain

• Abdominal swelling

• Dyspnea

Precautions and Warnings

• Patients with severe diarrhea should avoid Lubistone

• Evaluate for mechanical bowel obstruction before initiation

• Monitor infants for diarrhea if administered during breastfeeding

• Nausea may be reduced by taking the drug with food

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Overdose Effects

Symptoms may include: nausea, diarrhea, vomiting, dizziness, headache, abdominal pain, flushing, dyspnea, pallor, chest discomfort, dry mouth, hyperhidrosis, syncope, and anorexia. Supportive care is recommended in case of overdose.

Mode of Action

Lubistone 24 mcg enhances intestinal secretion and motility by activating ClC-2 chloride channels, promoting chloride and sodium efflux into the intestinal lumen. Water follows, increasing stool liquidity and intestinal transit. This mechanism provides effective relief from constipation while potentially aiding mucosal barrier recovery.

Pregnancy and Lactation

• Pregnancy: Category C. Use only if the potential benefit justifies the risk.

• Lactation: Unknown if excreted in breast milk; monitor infants for diarrhea. Use with caution in nursing women.

Storage

Store at 15–30°C, protected from light and moisture. Keep out of reach of children.