Lucrin Depot Injection 11.25 mg contains Leuprorelin Acetate, a synthetic gonadotropin-releasing hormone (GnRH) analog used for the management of hormone-sensitive conditions. Leuprorelin acts on the pituitary gland to initially stimulate, then suppress the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to reduced production of sex hormones, such as testosterone in men and estrogen in women.

The depot formulation of Lucrin provides sustained-release over 3 months, ensuring a stable therapeutic effect with fewer injections and improved compliance. This makes it suitable for long-term therapy in conditions such as prostate cancer, endometriosis, and certain gynecological disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Lucrin Depot Injection 11.25 mg is indicated for the treatment of:

• Prostate cancer: to suppress testosterone levels in patients with advanced or hormone-sensitive prostate carcinoma

• Endometriosis: to reduce estrogen production and relieve pain or lesions

• Uterine fibroids (leiomyoma): preoperative management to reduce fibroid size and associated symptoms

• Precocious puberty: to halt early onset puberty in children by suppressing gonadal hormone production

This depot injection is particularly advantageous for patients requiring long-term hormone suppression, reducing the need for frequent hospital visits or multiple injections.

Dosage and Administration

Recommended dosage:

• Adults: 11.25 mg administered as a single intramuscular or subcutaneous injection every 3 months

• Pediatric dosing for precocious puberty should be individualized based on weight, age, and clinical response

Administration guidelines:

• Administer as a deep intramuscular or subcutaneous injection in the upper arm, thigh, or buttock

• Ensure aseptic technique during administration

• Do not attempt to break, crush, or dissolve the depot formulation

• Follow the prescribed schedule strictly to maintain consistent hormone suppression

Precautions and Warnings

• Hypersensitivity: Avoid in patients with known allergy to Leuprorelin or any component of the formulation

• Hormonal effects: May cause hot flashes, reduced libido, mood changes, or injection site reactions

• Bone health: Long-term therapy may reduce bone mineral density; consider calcium and vitamin D supplementation

• Cardiovascular caution: Monitor in patients with heart disease, hypertension, or history of thromboembolism

• Pregnancy and breastfeeding: Contraindicated for use in pregnant or breastfeeding women

Patients should be monitored regularly with hormone levels, symptom assessment, and bone density evaluations as recommended by the physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Lucrin Depot Injection 11.25 mg is generally well tolerated. Common side effects include:

• Hot flashes, sweating, or flushing

• Headache, fatigue, or dizziness

• Injection site reactions such as pain, swelling, or redness

• Decreased libido or erectile dysfunction in men

• Menstrual irregularities in women

• Mood changes or depression

Rare but serious effects may include osteoporosis, cardiovascular events, or allergic reactions. Immediate medical attention is required if severe adverse effects occur.

Storage

Store in a cool, dry place at 2–8°C. Protect from light and do not freeze. Keep the vials in their original packaging and out of reach of children.

Lucrin Depot Injection 11.25 mg (Leuprorelin Acetate) provides long-acting hormone suppression, making it a reliable choice for managing hormone-sensitive conditions such as prostate cancer, endometriosis, and precocious puberty. Its depot formulation ensures sustained efficacy, convenience, and improved patient compliance.