Lucrin Depot Injection 3.75 mg contains Leuprorelin Acetate, a synthetic gonadotropin-releasing hormone (GnRH) analog used for the management of hormone-dependent conditions. Leuprorelin initially stimulates, then suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This leads to reduced production of sex hormones, including testosterone in men and estrogen in women, which is essential for controlling hormone-sensitive diseases.

The 3.75 mg depot formulation provides sustained release over one month, allowing monthly dosing and stable hormone suppression. This ensures convenience and compliance for patients requiring long-term therapy for conditions such as prostate cancer, endometriosis, uterine fibroids, and precocious puberty.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Lucrin Depot Injection 3.75 mg is indicated for:

• Prostate cancer: to reduce testosterone levels in patients with advanced or hormone-sensitive prostate carcinoma

• Endometriosis: to alleviate symptoms by suppressing estrogen production and minimizing endometrial growth

• Uterine fibroids (leiomyoma): preoperative treatment to reduce fibroid size and control heavy menstrual bleeding

• Precocious puberty: to halt early onset puberty in children by suppressing gonadal hormone production

This depot formulation is particularly useful for monthly management, providing consistent therapeutic levels without frequent hospital visits.

Dosage and Administration

Recommended dosage:

• Adults: 3.75 mg administered as a single intramuscular or subcutaneous injection every 4 weeks

• Pediatric dosing for precocious puberty should be individualized based on age, weight, and clinical response

Administration guidelines:

• Administer as a deep intramuscular or subcutaneous injection in the buttock, thigh, or upper arm

• Ensure aseptic technique during preparation and injection

• Do not break, crush, or dissolve the depot formulation

• Maintain a strict monthly schedule to ensure continuous hormone suppression

Precautions and Warnings

• Hypersensitivity: Avoid in patients with known allergy to Leuprorelin or any excipients in the formulation

• Hormonal effects: May cause hot flashes, sweating, mood changes, or injection site reactions

• Bone health: Prolonged therapy may reduce bone mineral density; consider calcium and vitamin D supplementation

• Cardiovascular caution: Monitor in patients with a history of heart disease, hypertension, or thromboembolic events

• Pregnancy and breastfeeding: Contraindicated for use in pregnant or lactating women

Regular monitoring of hormone levels, clinical symptoms, and bone density is recommended to ensure safety and efficacy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Lucrin Depot Injection 3.75 mg is generally well tolerated. Common side effects may include:

• Hot flashes, sweating, or flushing

• Headache, fatigue, or dizziness

• Injection site reactions such as pain, redness, or swelling

• Decreased libido or erectile dysfunction in men

• Menstrual irregularities in women

• Mood changes or depression

Rare but serious adverse effects include osteoporosis, cardiovascular events, or severe allergic reactions. Patients should seek immediate medical attention if serious symptoms occur.

Storage

Store in a cool, dry place at 2–8°C, protected from light and freezing. Keep the vial in its original packaging and out of reach of children.

Lucrin Depot Injection 3.75 mg (Leuprorelin Acetate) provides effective, long-term hormone suppression with monthly dosing, making it ideal for patients with hormone-dependent conditions such as prostate cancer, endometriosis, uterine fibroids, and precocious puberty. Its depot formulation ensures consistent efficacy, convenience, and improved patient compliance.