Maxima Tablet 20 mg contains Esomeprazole, a proton pump inhibitor (PPI) used for the effective treatment of acid-related gastrointestinal disorders. It works by reducing the amount of acid produced in the stomach, thereby relieving symptoms and promoting healing of the damaged mucosa.

Esomeprazole is the S-isomer of omeprazole and provides improved acid suppression compared to racemic proton pump inhibitors. By targeting the final step of acid production, Maxima Tablet 20 mg offers sustained control of gastric acidity and long-lasting symptom relief.

This medication is commonly prescribed for patients experiencing heartburn, acid reflux, peptic ulcers, and other conditions associated with excessive gastric acid secretion.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Proton Pump Inhibitor (PPI)

• Anti-ulcerant

Indications

Maxima Tablet 20 mg is indicated for:

• Gastroesophageal Reflux Disease (GERD)

• Symptomatic relief of persistent heartburn

• Healing of erosive esophagitis

• Maintenance of healed erosive esophagitis

• Duodenal ulcer

• Gastric ulcer

• Acid-related dyspepsia

• Part of combination therapy for eradication of Helicobacter pylori infection

By reducing acid secretion, Maxima 20 mg helps minimize mucosal irritation and supports long-term gastrointestinal health.

Dosage & Administration

The recommended dosage depends on the condition being treated:

• Symptomatic GERD: 20 mg once daily for 4 weeks

• Healing of Erosive Esophagitis: 20 mg once daily for 4–8 weeks

• Maintenance Therapy: 20 mg once daily

• Duodenal Ulcer: 20 mg once daily for 2–4 weeks

• Gastric Ulcer: 20 mg once daily for 4–8 weeks

• H. pylori Eradication: 20 mg or 40 mg once daily in combination with appropriate antibiotics

The tablet should be taken at least one hour before meals and swallowed whole with water. Do not crush or chew the tablet.

Pharmacology

Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (proton pump) in gastric parietal cells. This enzyme is responsible for the final step in acid production. By blocking this mechanism, esomeprazole suppresses both basal and stimulated acid secretion.

After oral administration, peak plasma concentration occurs approximately 1.5 hours later. The drug is about 97% bound to plasma proteins and is metabolized in the liver primarily via CYP2C19 and CYP3A4 enzymes. The elimination half-life is approximately 1–1.5 hours. Around 80% of the administered dose is excreted in urine as inactive metabolites.

Drug Interactions

Esomeprazole may:

• Reduce absorption of drugs dependent on gastric pH (e.g., ketoconazole, iron salts, digoxin)

• Reduce clearance of diazepam

• Show increased levels when used with clarithromycin

• Have minimal clinically significant interaction with phenytoin, warfarin, quinidine, or oral contraceptives

Contraindications

Maxima Tablet 20 mg is contraindicated in patients with:

• Known hypersensitivity to esomeprazole

• Allergy to substituted benzimidazoles

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Headache

• Diarrhea

• Nausea

• Abdominal pain

• Constipation

• Flatulence

• Dry mouth

Most adverse reactions are mild and self-limiting.

Precautions & Warnings

• Symptom relief does not rule out gastric malignancy.

• Use caution in severe hepatic impairment.

• Long-term use may be associated with vitamin B12 deficiency or hypomagnesemia.

• Not recommended in pediatric patients unless advised by a specialist.

Pregnancy & Lactation

Adequate human studies are lacking. Use during pregnancy only if clearly necessary. Breastfeeding should be discontinued if therapy is essential.

Storage Conditions

Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.