Melphalan Injection 50 mg/vial contains Melphalan, an alkylating chemotherapeutic agent used for the treatment of various hematologic malignancies and solid tumors. Melphalan works by interfering with DNA replication and transcription, leading to cancer cell death and slowing the progression of malignancies.

This injectable formulation allows direct intravenous administration, ensuring precise dosing and rapid bioavailability for patients requiring systemic chemotherapy. Melphalan is commonly used in the management of multiple myeloma, ovarian cancer, and breast cancer, either alone or in combination with other chemotherapeutic agents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Melphalan 50 mg

Mechanism of Action

Melphalan is a nitrogen mustard derivative that functions as an alkylating agent:

• Forms cross-links in DNA strands, preventing replication and transcription

• Induces cell cycle arrest and apoptosis in rapidly dividing cancer cells

• Reduces tumor growth and malignancy progression

This mechanism selectively targets rapidly proliferating malignant cells, while normal cells are affected to a lesser extent.

Indications

Melphalan Injection 50 mg/vial is indicated for:

• Multiple myeloma

• Ovarian carcinoma

• Breast cancer

• As part of conditioning regimens prior to bone marrow transplantation

• Other hematologic or solid malignancies as prescribed by an oncologist

Dosage and Administration

• Administer only under the supervision of a qualified healthcare professional

• Dose and schedule depend on type of malignancy, patient weight, age, and overall health

• Usually given intravenously over several minutes or as specified in the protocol

• Monitor blood counts, liver and kidney function before and during treatment

• Use aseptic technique to prepare and administer the injection

Precautions

• Bone marrow suppression is common; monitor for neutropenia, thrombocytopenia, and anemia

• Avoid use in patients with severe bone marrow failure

• May cause secondary malignancies with long-term use

• Pregnancy and breastfeeding are contraindicated

• Handle with care to avoid exposure to healthcare personnel

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Nausea and vomiting

• Bone marrow suppression (low blood counts)

• Fatigue

• Loss of appetite

Serious side effects may include:

• Severe infections due to neutropenia

• Bleeding tendencies from thrombocytopenia

• Allergic reactions at the injection site

• Secondary malignancies or organ toxicity

Close medical monitoring is essential during therapy.

Storage

• Store below 25°C

• Protect from light and moisture

• Keep out of reach of children.