Metonid Injection 500 mg/100 ml contains Metronidazole, a widely used antimicrobial agent effective against anaerobic bacteria and certain protozoa. It is administered intravenously for the treatment of serious infections where oral therapy is not feasible or appropriate. This formulation ensures rapid delivery and reliable therapeutic levels in systemic infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metronidazole 500 mg per 100 ml
• Dosage Form: Intravenous infusion

Indications

Metonid Injection is indicated for the treatment of:

• Anaerobic bacterial infections (e.g., intra-abdominal infections, pelvic infections)
• Septicemia caused by susceptible organisms
• Gynecological infections including endometritis
• Skin and soft tissue infections
• Bone and joint infections
• Protozoal infections such as amoebiasis
• Prevention of post-operative infections, especially in colorectal or gynecological surgeries

Mechanism of Action

Metronidazole works by entering microbial cells and disrupting DNA synthesis, leading to cell death. Its action includes:

• Effective killing of anaerobic bacteria
• Activity against protozoa such as Entamoeba histolytica
• Prevention of infection spread in oxygen-poor environments

Dosage and Administration

• Administered as intravenous infusion under medical supervision
• Typical adult dose: 500 mg every 8 hours or as directed by a physician
• Infusion should be given slowly over 20–60 minutes
• Dosage may vary depending on the severity and type of infection

Side Effects

Common side effects:

• Nausea and vomiting
• Metallic taste
• Headache
• Injection site reactions

Serious side effects:

• Peripheral neuropathy (long-term use)
• Seizures (rare)
• Allergic reactions
• Dark-colored urine

Precautions and Warnings

• Avoid alcohol during treatment and for at least 48 hours after completion (risk of disulfiram-like reaction)
• Use with caution in patients with liver impairment
• Monitor for neurological symptoms during prolonged therapy
• Use in pregnancy only if clearly necessary

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Alcohol may cause severe adverse reactions
• May enhance the effect of warfarin and other anticoagulants
• Interaction with drugs like phenytoin and phenobarbital may alter effectiveness

Storage Conditions

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children.