Metorax Injection 50 mg/2 ml contains Methotrexate, a powerful antimetabolite and immunosuppressive agent used for the treatment of various cancerous and autoimmune disorders. Methotrexate works by inhibiting dihydrofolate reductase, an enzyme critical for DNA, RNA, and protein synthesis, effectively slowing the growth of rapidly dividing cells.

This injectable formulation provides rapid and precise dosing, making it suitable for acute therapy in oncology and severe autoimmune conditions where oral administration is not feasible.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 2 ml vial contains:

• Methotrexate 50 mg

Mechanism of Action

Methotrexate is an antifolate chemotherapeutic agent that:

• Inhibits dihydrofolate reductase, blocking nucleotide synthesis

• Suppresses proliferation of rapidly dividing cancer cells

• Modulates immune system activity, reducing inflammation in autoimmune diseases

By targeting DNA synthesis and cell division, Methotrexate is effective for both oncological and rheumatological treatments.

Indications

Metorax Injection 50 mg/2 ml is indicated for:

• Acute lymphoblastic leukemia and other malignancies

• Severe rheumatoid arthritis

• Psoriasis and other autoimmune disorders requiring parenteral therapy

• Situations where oral Methotrexate is not suitable

Dosage and Administration

• Administer under strict medical supervision

• Intravenous, intramuscular, or subcutaneous injection as prescribed

• Dose and frequency vary based on disease type, patient weight, and treatment protocol

• Monitor blood counts, liver, and kidney function during therapy

• Avoid extravasation and ensure proper aseptic technique

Precautions

• Contraindicated in pregnancy and breastfeeding

• Use with caution in patients with liver or kidney impairment

• Monitor for bone marrow suppression, infections, hepatotoxicity, and pulmonary complications

• Avoid concurrent use with drugs that increase Methotrexate toxicity unless prescribed by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Nausea and vomiting

• Mouth ulcers or gastrointestinal irritation

• Fatigue

Serious side effects may include:

• Bone marrow suppression (low blood counts)

• Severe infections due to immunosuppression

• Liver toxicity or fibrosis

• Pulmonary toxicity (pneumonitis)

Seek immediate medical attention for severe infections, unusual bleeding, or breathing difficulties.

Storage

• Store below 25°C

• Protect from light

• Keep out of reach of children

• Use immediately after reconstitution or follow storage guidelines strictly.