NapExa Tablet 375 mg + 20 mg is a combination medication containing Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). This dual-action formulation is designed to provide effective pain and inflammation relief while reducing the risk of stomach irritation and ulcer formation commonly associated with long-term NSAID therapy.

This combination is particularly beneficial for patients who require ongoing anti-inflammatory treatment but are at risk of gastrointestinal complications. By addressing both pain and gastric protection in a single tablet, NapExa improves treatment convenience and safety.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Naproxen Sodium 375 mg

• Esomeprazole Magnesium 20 mg

Mechanism of Action

Naproxen Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the production of prostaglandins. These substances play a key role in inflammation, pain, and fever. By reducing prostaglandin synthesis, naproxen effectively relieves pain, swelling, and stiffness.

Esomeprazole Magnesium reduces gastric acid secretion by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining. This action helps protect the stomach and upper intestine from acid-related irritation and reduces the risk of ulcers caused by NSAIDs.

Indications

NapExa Tablet 375 mg + 20 mg is indicated for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic musculoskeletal pain

• Patients requiring NSAID therapy with a risk of gastric ulcers

It is suitable for individuals who need long-term anti-inflammatory treatment along with gastric protection.

Dosage and Administration

The dosage should be determined by a registered physician based on the patient’s condition and medical history. NapExa is usually taken as directed, often once or twice daily.

The tablet should be swallowed whole with water and not crushed, chewed, or split, as it is specially formulated to deliver both medications appropriately. It may be taken before meals unless otherwise advised by a healthcare professional.

Benefits

• Effective relief from pain and inflammation

• Reduces joint stiffness and swelling

• Provides built-in gastric protection

• Convenient combination therapy in a single tablet

• Suitable for long-term management under medical supervision

Possible Side Effects

Common side effects may include:

• Indigestion

• Nausea

• Abdominal discomfort

• Headache

• Dizziness

Serious but less common side effects may include gastrointestinal bleeding, kidney problems, or cardiovascular events. Seek immediate medical attention if symptoms such as severe stomach pain, black stools, chest pain, or shortness of breath occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with a history of heart disease, hypertension, kidney impairment, or gastrointestinal disorders.

• Avoid use during the third trimester of pregnancy.

• Inform the physician about all other medications to prevent interactions.

• Long-term therapy requires regular medical monitoring.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

NapExa Tablet 375 mg + 20 mg offers effective anti-inflammatory relief with added stomach protection, making it a practical and safer choice for patients requiring ongoing NSAID therapy.