Naprosyn Plus Tablet combines Naproxen Sodium 375 mg, a nonsteroidal anti-inflammatory drug (NSAID), with Esomeprazole Magnesium 20 mg, a proton pump inhibitor (PPI). This dual-action formulation is designed to provide effective relief from pain and inflammation while reducing the risk of NSAID-induced gastric irritation and ulcers.

Naproxen Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes responsible for the production of prostaglandins, which cause pain, inflammation, and swelling. Esomeprazole Magnesium reduces stomach acid production by blocking the proton pump in gastric parietal cells, thereby protecting the stomach lining from acid-related damage.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Effective relief from moderate pain and inflammation

• Reduces joint stiffness and swelling

• Protects the stomach from NSAID-related gastric irritation

• Suitable for patients requiring long-term anti-inflammatory therapy

• Convenient combination therapy in a single tablet

Indications

Naprosyn Plus Tablet is indicated for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic musculoskeletal pain

• Patients at risk of NSAID-induced gastric ulcers

• Other inflammatory conditions requiring gastric protection.

Dosage and Administration

• The usual dose is one tablet once or twice daily, as prescribed by a physician.

• Swallow the tablet whole with water. Do not crush or chew.

• It is generally recommended to take before meals.

• Follow the healthcare provider’s instructions regarding dose and duration.

Mechanism of Action

Naproxen Sodium reduces inflammation and pain by inhibiting prostaglandin synthesis through COX enzyme inhibition.
Esomeprazole Magnesium decreases gastric acid secretion by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme system (proton pump) in the stomach.

The combination provides effective anti-inflammatory therapy with improved gastrointestinal safety.

Safety Information

Contraindications:

• Hypersensitivity to naproxen, esomeprazole, other NSAIDs, or PPIs

• Active gastrointestinal bleeding

• Severe liver impairment

• History of NSAID-induced asthma

Warnings and precautions:

• May increase the risk of cardiovascular events with long-term use

• Use cautiously in patients with kidney, liver, or heart disease

• Long-term PPI use may be associated with vitamin B12 deficiency or bone fracture risk

• Avoid use during the third trimester of pregnancy

Common side effects may include abdominal discomfort, nausea, headache, dizziness, diarrhea, or constipation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.