Naprosyn Plus Tablet 500 mg + 20 mg is a combination medication containing Naproxen Sodium 500 mg, a nonsteroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium 20 mg, a proton pump inhibitor (PPI). This formulation is designed to provide strong and sustained relief from pain and inflammation while minimizing the risk of stomach irritation commonly associated with long-term NSAID use.

Naproxen Sodium reduces inflammation and pain by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes responsible for prostaglandin synthesis. Esomeprazole Magnesium works by suppressing gastric acid secretion through inhibition of the H⁺/K⁺-ATPase (proton pump) in stomach parietal cells, thereby protecting the gastric mucosa.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Powerful relief from moderate to severe inflammatory pain

• Reduces joint swelling, stiffness, and tenderness

• Provides gastric protection against NSAID-induced ulcers

• Suitable for long-term arthritis management under medical supervision

• Convenient fixed-dose combination therapy

Indications

Naprosyn Plus Tablet 500 mg + 20 mg is indicated for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic musculoskeletal disorders

• Patients at risk of NSAID-associated gastric ulcers

• Other inflammatory conditions requiring both pain control and gastric protectionk,

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• The usual recommended dose is one tablet once or twice daily, as prescribed by a healthcare provider.

• Swallow the tablet whole with water; do not crush or chew.

• Generally taken before meals for optimal effect.

• Use the lowest effective dose for the shortest duration necessary.

Always follow the physician’s instructions regarding dose and treatment duration.

Mechanism of Action

Naproxen Sodium reduces inflammation and pain by blocking COX enzymes and decreasing prostaglandin production.
Esomeprazole Magnesium reduces gastric acid secretion by irreversibly inhibiting the proton pump in stomach cells, lowering the risk of ulcer formation.

The combination ensures effective anti-inflammatory therapy with improved gastrointestinal safety.

Safety Information

Contraindications:

• Known hypersensitivity to naproxen, esomeprazole, NSAIDs, or PPIs

• Active gastrointestinal bleeding or peptic ulcer

• Severe hepatic impairment

• History of NSAID-induced asthma

Warnings and precautions:

• May increase the risk of cardiovascular events with prolonged use

• Monitor kidney function during long-term therapy

• Long-term PPI use may increase the risk of vitamin B12 deficiency, hypomagnesemia, or bone fractures

• Avoid use during the third trimester of pregnancy

Common side effects may include abdominal pain, nausea, dyspepsia, diarrhea, headache, and dizziness.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.