Nystat Suspension 100,000 Unit/ml contains Nystatin, a potent antifungal medication used to treat infections caused by Candida species in the oral cavity and gastrointestinal tract. Available as a liquid suspension, it is particularly suitable for infants, children, and adults who have difficulty swallowing tablets, providing accurate dosing and effective local antifungal action.

Nystatin belongs to the polyene antifungal class, which works by disrupting the fungal cell membrane. It binds to ergosterol, a key component of fungal cell walls, causing leakage of cellular contents and ultimately leading to fungal cell death. Since Nystatin is minimally absorbed from the gastrointestinal tract, it primarily acts locally, making it safe and effective for treating oral thrush, esophageal candidiasis, and intestinal yeast infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Nystat Suspension is indicated for:

• Oral candidiasis (thrush) in infants, children, and adults

• Esophageal or gastrointestinal candidiasis

• Fungal overgrowth in immunocompromised patients

• Prevention of Candida infections in patients on prolonged antibiotic therapy

• Supportive therapy for patients prone to fungal infections due to illness or medication

Mechanism of Action

Nystatin acts through a targeted antifungal mechanism:

1. Binding to Ergosterol: Nystatin attaches to ergosterol in the fungal cell membrane.

2. Disrupting Membrane Integrity: This binding creates pores in the membrane, causing leakage of essential cellular contents.

3. Fungal Cell Death: The loss of cell integrity leads to the death of the fungus while sparing human cells, as mammalian cells do not contain ergosterol.

The local action of Nystatin ensures high effectiveness against Candida species in the mouth and gastrointestinal tract while minimizing systemic side effects.

Dosage and Administration

The dosage of Nystat Suspension depends on the patient’s age and the severity of the infection:

• Infants and children: Usually 1–2 ml four times daily, adjusted based on physician guidance.

• Adults: Typically 4–6 ml daily, divided into 3–4 doses.

• Shake the suspension well before each use for uniform distribution.

• Swish in the mouth for a few seconds before swallowing to maximize contact with oral lesions.

• Complete the full course of therapy, even if symptoms improve earlier, to prevent recurrence.

A calibrated measuring spoon or oral syringe should be used for precise dosing.

Precautions and Warnings

• Consult a physician before use if the patient has liver disease or other chronic medical conditions.

• Avoid use in patients with known hypersensitivity to Nystatin or other polyene antifungals.

• Not effective for systemic fungal infections due to minimal absorption.

• Inform the doctor if pregnant or breastfeeding before use.

Possible Side Effects

Nystat Suspension is generally safe and well-tolerated. Mild side effects may include:

• Nausea or vomiting

• Diarrhea

• Stomach discomfort

• Rare allergic reactions such as rash or itching

Seek medical attention if severe side effects or signs of hypersensitivity occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store the suspension below 30°C in a dry place, protected from direct sunlight. Keep tightly closed and out of reach of children.

Nystat Suspension 100,000 Unit/ml provides a safe, effective, and convenient solution for treating oral and gastrointestinal Candida infections, ensuring optimal antifungal therapy, especially for infants and patients who cannot swallow tablets.