Obexa Tablet 5 mg contains Obeticholic Acid, a selective farnesoid X receptor (FXR) agonist used in the treatment of primary biliary cholangitis (PBC), a chronic autoimmune liver disorder that causes progressive destruction of the bile ducts. It is prescribed for adult patients who have an inadequate response to ursodeoxycholic acid (UDCA) or who cannot tolerate UDCA therapy.

Obeticholic Acid works by regulating bile acid synthesis and transport within the liver. By reducing bile acid accumulation and improving bile flow, it helps decrease liver inflammation and may slow the progression of liver damage.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Reduces bile acid buildup in the liver

• Improves liver function test parameters

• Slows progression of primary biliary cholangitis

• Can be used alone or alongside UDCA

• Supports long-term liver disease management

Indications

Obexa Tablet 5 mg is indicated for:

• Treatment of primary biliary cholangitis (PBC) in adults

  • In combination with ursodeoxycholic acid in patients with inadequate response

  • As monotherapy in patients intolerant to ursodeoxycholic acid.

Dosage and Administration

• The recommended starting dose is 5 mg once daily.

• Depending on tolerability and biochemical response, the dose may be increased as directed by a healthcare provider.

• May be taken with or without food.

• Regular monitoring of liver function tests is essential during treatment.

Dose adjustments are required in patients with moderate to severe hepatic impairment, and careful supervision is necessary.

Mechanism of Action

Obeticholic Acid activates the farnesoid X receptor (FXR), a nuclear receptor that regulates bile acid homeostasis. Activation of FXR leads to:

• Decreased bile acid synthesis

• Increased bile acid transport and excretion

• Reduced liver inflammation and fibrosis

These effects help improve biochemical markers and may delay disease progression in PBC patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Safety Information

Contraindications:

• Complete biliary obstruction

• Hypersensitivity to obeticholic acid

Warnings and precautions:

• May worsen liver function in patients with advanced cirrhosis

• Regular monitoring of liver enzymes and bilirubin is required

• Pruritus (itching) is the most common side effect

• Use cautiously in patients with hepatic impairment

Common side effects may include:

• Itching (pruritus)

• Fatigue

• Abdominal pain

• Joint discomfort

Patients should seek medical attention if symptoms of liver decompensation (e.g., jaundice, swelling, worsening fatigue) occur.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.