Paloxi Injection 0.075 mg/1.5 ml contains Palonosetron, a second-generation serotonin (5-HT3) receptor antagonist. It is used for the prevention and treatment of nausea and vomiting caused by chemotherapy, radiotherapy, and surgical procedures. Palonosetron has a longer duration of action compared to earlier agents, providing extended antiemetic protection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Palonosetron Hydrochloride
• Strength: 0.075 mg per 1.5 ml

Mechanism of Action

Palonosetron works by selectively blocking 5-HT3 receptors located in the central nervous system and gastrointestinal tract. These receptors are responsible for triggering nausea and vomiting reflexes when stimulated by chemotherapy or other emetogenic stimuli. By inhibiting this pathway, Palonosetron effectively prevents acute and delayed nausea and vomiting.

Indications

Paloxi Injection is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV)
• Prevention of postoperative nausea and vomiting (PONV)
• Supportive care in radiotherapy-induced nausea and vomiting

Dosage and Administration

• Administered intravenously by a healthcare professional only
• Given prior to chemotherapy or surgical procedures as prescribed
• Dosage and timing depend on clinical protocol and patient condition
• Should not be self-administered

Benefits

• Provides long-lasting protection against nausea and vomiting
• Effective for both acute and delayed chemotherapy-induced nausea
• Improves patient comfort and treatment tolerance
• Reduces need for additional antiemetic medications

Possible Side Effects

Common side effects may include:

• Headache
• Constipation
• Dizziness
• Fatigue
• Mild injection site reactions

Serious side effects are rare but may include hypersensitivity reactions.

Precautions and Warnings

• Use only under medical supervision
• Caution in patients with cardiac conditions or arrhythmias
• Inform doctor about all ongoing medications
• Dose adjustment may be required in severe liver impairment
• Not intended for routine self-use

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store in a cool and dry place
• Protect from light
• Do not freeze
• Keep out of reach of children

Conclusion

Paloxi Injection 0.075 mg/1.5 ml (Palonosetron) is an effective antiemetic used for preventing nausea and vomiting associated with chemotherapy, radiotherapy, and surgery. It provides long-lasting symptom control and improves patient comfort under proper medical supervision.