Pentasa Microgranules 2 gm/sachet contains Mesalazine (5-aminosalicylic acid or 5-ASA), an anti-inflammatory medicine used in the treatment of inflammatory bowel diseases (IBD). The prolonged-release microgranule formulation ensures that mesalazine is gradually released throughout the gastrointestinal tract, including both the small intestine and colon, where it exerts its therapeutic effect.

Mesalazine acts locally on the inflamed intestinal mucosa to reduce inflammation, relieve symptoms, and help maintain long-term remission in chronic bowel disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Effectively reduces intestinal inflammation

• Controls symptoms such as diarrhea, abdominal pain, and rectal bleeding

• Supports maintenance of remission in ulcerative colitis

• Prolonged-release formulation for targeted intestinal action

• Suitable for moderate disease activity requiring higher doses

Indications

Pentasa Microgranules 2 gm/sachet is indicated for:

• Mild to moderate ulcerative colitis

• Maintenance of remission in ulcerative colitis

• Crohn’s disease affecting the small intestine and colon

• Other inflammatory bowel conditions as prescribed by a physician.

Dosage and Administration

• The dosage depends on the severity of the disease and clinical response.

• Typical adult dosing ranges from 2–4 gm daily in divided doses, as directed by a healthcare provider.

• The contents of the sachet may be placed directly on the tongue and swallowed with water or mixed with a small amount of water or soft food.

• Do not crush or chew the microgranules to preserve the prolonged-release properties.

Always follow the prescribing physician’s instructions regarding dose and duration of therapy.

Mechanism of Action

Mesalazine acts topically within the intestinal lining. It works by:

• Inhibiting inflammatory mediators such as prostaglandins and leukotrienes

• Reducing cytokine production

• Decreasing oxidative damage in the intestinal mucosa

These actions help reduce inflammation and promote healing of the bowel lining.

Safety Information

Contraindications:

• Hypersensitivity to mesalazine or other salicylates

• Severe renal impairment

Warnings and precautions:

• Renal function should be assessed before and during treatment

• Use cautiously in patients with hepatic impairment

• Rare cases of blood dyscrasias have been reported; monitoring may be required

• Seek medical advice if severe abdominal pain, fever, or rash occurs

Common side effects may include:

• Headache

• Nausea

• Abdominal discomfort

• Diarrhea

Serious adverse reactions are uncommon but require prompt medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.