Pirfedone Tablet 801 mg contains Pirfenidone, a potent antifibrotic and anti-inflammatory agent used for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a progressive lung disorder characterized by irreversible scarring of lung tissue, which impairs oxygen transfer, leads to chronic shortness of breath, fatigue, and significantly impacts quality of life.

Pirfenidone works by targeting the fibrotic and inflammatory pathways involved in the progression of IPF. It inhibits the activity of transforming growth factor-beta (TGF-β), a key mediator in collagen deposition and fibroblast proliferation, while also reducing the production of inflammatory cytokines such as TNF-alpha and interleukin-1. This dual mechanism helps slow disease progression, preserve lung function, and improve patient outcomes.

The 801 mg tablet provides a high-dose formulation for adult patients, facilitating the attainment of the recommended daily dose while simplifying the dosing schedule. Pirfedone is typically administered orally in multiple doses throughout the day with food to enhance absorption and minimize gastrointestinal discomfort. Long-term adherence is essential to maintain therapeutic drug levels and achieve maximum antifibrotic effect.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Pirfenidone 801 mg per tablet

• Antifibrotic and anti-inflammatory therapy for idiopathic pulmonary fibrosis

• Slows progression of lung scarring and preserves respiratory function

• Oral tablet for convenient and effective long-term therapy

• Improves exercise tolerance, oxygenation, and quality of life

• High-dose formulation suitable for titrated therapy under specialist supervision

Indications

Pirfedone Tablet 801 mg is indicated for:

• Idiopathic Pulmonary Fibrosis (IPF): To slow the progression of fibrosis and maintain lung function

• Fibrosis-related respiratory conditions: Prescribed under specialist guidance when indicated

• Supportive therapy: Helps patients maintain functional capacity and quality of life

The medication must be used under the care of a pulmonologist or qualified healthcare professional, with regular monitoring of lung function, liver, and kidney parameters.

Mechanism of Action

Pirfenidone’s therapeutic effect is achieved through a combination of antifibrotic and anti-inflammatory actions:

• Inhibition of TGF-β and collagen synthesis: Reduces fibroblast activity and extracellular matrix deposition, slowing fibrotic tissue formation

• Suppression of inflammatory cytokines: Lowers TNF-alpha and interleukin-1 levels to prevent additional tissue damage

• Preservation of lung structure and function: Helps maintain lung elasticity, oxygenation, and overall respiratory capacity

This dual action addresses both the fibrotic and inflammatory components of IPF, providing comprehensive management of the disease.

Dosage and Administration

• Typically administered orally three times daily with food

• Gradual dose titration is recommended to reach the full therapeutic dose while minimizing side effects

• Regular monitoring of liver and kidney function is essential

• Dose adjustments may be required in patients with hepatic or renal impairment

• Adherence to the prescribed dosing schedule is critical for effectiveness

Possible Side Effects

Common side effects include:

• Nausea, vomiting, or diarrhea

• Loss of appetite

• Fatigue, dizziness, or headache

• Rash or photosensitivity

• Mild gastrointestinal discomfort

Serious but rare side effects:

• Liver function abnormalities

• Severe skin reactions or photosensitivity

• Allergic reactions

• Persistent gastrointestinal issues requiring medical attention

Patients should report any severe or unusual symptoms to their healthcare provider immediately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use only under specialist supervision

• Avoid direct sunlight and use protective measures to prevent photosensitivity reactions

• Regular liver and kidney function monitoring is recommended

• Inform your physician about all concurrent medications to avoid interactions

• Not recommended during pregnancy or breastfeeding without medical supervision

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep tablets in the original container, tightly closed

• Keep out of reach of children.