Pladex-A Tablet 75 mg + 75 mg is a combination antiplatelet therapy containing Clopidogrel and Aspirin, formulated to provide enhanced cardiovascular protection in patients at risk of thrombotic events. This dual-action tablet is specifically designed to prevent heart attacks, strokes, and complications related to acute coronary syndrome, especially in patients with a history of arterial blockages or undergoing percutaneous coronary intervention (PCI).

Clopidogrel works by inhibiting platelet aggregation through selective P2Y12 receptor blockade, while Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1), reducing thromboxane A2 production and further preventing platelet clumping. The combination ensures a synergistic effect, offering stronger and more consistent prevention of arterial clot formation compared to monotherapy.

Pladex-A is ideal for long-term management in high-risk cardiovascular patients, providing both convenience and efficacy with a single daily tablet.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Active Ingredients: Clopidogrel 75 mg + Aspirin 75 mg – dual antiplatelet therapy for superior clot prevention.

• Reduces Risk of Heart Attack and Stroke: Protects patients with cardiovascular disease or high-risk profiles.

• Prevents Arterial Blockages: Inhibits platelet aggregation via two complementary mechanisms.

• Supports Acute Coronary Syndrome Management: Effective in unstable angina and post-PCI care.

• Single Oral Tablet: Convenient once-daily dosing for long-term therapy.

Indications

Pladex-A Tablet 75 mg + 75 mg is indicated for:

• Prevention of atherothrombotic events in patients with a history of heart attack, stroke, or peripheral arterial disease

• Management of acute coronary syndrome (unstable angina or NSTEMI)

• Post-percutaneous coronary intervention (PCI) to maintain arterial patency

• Long-term prevention of thrombotic cardiovascular complications in high-risk patients

Mechanism of Action

The combination of Clopidogrel and Aspirin in Pladex-A provides dual inhibition of platelet activity:

1. Clopidogrel: Blocks the ADP P2Y12 receptor on platelets, preventing activation and aggregation.

2. Aspirin: Irreversibly inhibits COX-1 enzyme, reducing thromboxane A2 production and further limiting platelet aggregation.

3. Synergistic Effect: Both drugs together reduce the risk of thrombus formation more effectively than either drug alone.

This dual mechanism ensures enhanced protection against arterial blockages and thrombotic events.

Dosage and Administration

• Adults: 1 tablet once daily, orally, with or without food, or as directed by a physician.

• Typically prescribed for long-term use in high-risk cardiovascular patients.

• Swallow the tablet whole; do not crush or chew.

• Follow the physician’s instructions for therapy duration, particularly after PCI or acute coronary events.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Safety and Precautions

• May increase the risk of bleeding; use with caution in patients with active gastrointestinal bleeding, peptic ulcers, or hemorrhagic disorders.

• Monitor for signs of unusual bruising, prolonged bleeding, or black/tarry stools.

• Inform your doctor about all medications to avoid interactions, especially with anticoagulants or other antiplatelet agents.

• Use cautiously in patients with liver impairment or history of hypersensitivity to Clopidogrel or Aspirin.

• Store in a cool, dry place below 25°C, away from moisture and light, and out of reach of children.

Pladex-A Tablet 75 mg + 75 mg provides effective dual antiplatelet therapy, reducing the risk of heart attacks, strokes, and thrombotic complications while supporting long-term cardiovascular health.