Prelizer-HTZ Tablet 2.5 mg + 6.25 mg is a fixed-dose combination medicine containing Bisoprolol Fumarate 2.5 mg and Hydrochlorothiazide 6.25 mg. It is primarily used for the treatment of hypertension (high blood pressure), particularly in patients who require combination therapy for better blood pressure control.

This combination works through two complementary mechanisms: bisoprolol reduces heart rate and cardiac workload, while hydrochlorothiazide helps eliminate excess salt and water from the body. Together, they provide effective and sustained blood pressure reduction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Prelizer-HTZ is indicated for:

• Hypertension not adequately controlled with single-agent therapy

• Patients requiring low-dose combination therapy for improved cardiovascular protection

Proper blood pressure management significantly reduces the risk of stroke, heart attack, heart failure, and kidney complications.

Dosage and Administration

• Usually taken once daily, preferably in the morning.

• Can be taken with or without food.

• Swallow the tablet whole with water.

• Dose adjustments should be made by a physician based on clinical response.

Do not discontinue abruptly without medical supervision, especially due to the beta-blocker component.

Mechanism of Action

Bisoprolol is a selective beta-1 adrenergic receptor blocker that:

• Slows heart rate

• Reduces cardiac output

• Lowers blood pressure

Hydrochlorothiazide is a thiazide diuretic that:

• Increases urinary excretion of sodium and water

• Reduces blood volume

• Lowers blood pressure

The combination provides additive antihypertensive effects.

Benefits

• Dual mechanism for improved blood pressure control

• Once-daily convenient dosing

• Lower doses may reduce side effect risk

• Helps prevent cardiovascular complications

• Suitable for long-term hypertension management

Safety Information

Contraindications

• Severe bradycardia

• Cardiogenic shock

• Severe renal impairment

• Anuria

• Hypersensitivity to sulfonamides or any component

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Warnings and Precautions

• Monitor blood pressure and heart rate regularly

• Monitor electrolytes (potassium, sodium)

• May mask symptoms of hypoglycemia in diabetic patients

• Use cautiously in patients with gout or kidney disease

• Avoid abrupt discontinuation

Common Side Effects

• Dizziness

• Fatigue

• Increased urination

• Electrolyte imbalance

• Slow heart rate

Seek medical attention if experiencing severe dizziness, fainting, irregular heartbeat, or allergic reactions.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.