Primace Capsule 10 mg contains Ramipril, an angiotensin-converting enzyme (ACE) inhibitor used primarily for the management of hypertension, heart failure, and cardiovascular risk reduction. It helps to lower high blood pressure, improve heart function, and prevent complications associated with cardiovascular disease such as stroke, myocardial infarction, and kidney damage in patients with diabetes or renal impairment.

Ramipril works by inhibiting the ACE enzyme, which is responsible for converting angiotensin I to angiotensin II—a potent vasoconstrictor. By reducing the production of angiotensin II, Ramipril causes vasodilation, decreases peripheral vascular resistance, and reduces blood pressure. Additionally, it lowers aldosterone secretion, leading to reduced sodium and water retention, which further supports its antihypertensive and cardioprotective effects.

Primace is available as an oral capsule, providing convenient once-daily dosing. Its long-lasting effect and well-established safety profile make it a preferred choice in both chronic management and cardiovascular risk prevention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Primace Capsule 10 mg is indicated for:

• Hypertension: For lowering elevated blood pressure to reduce the risk of cardiovascular events

• Heart Failure: Adjunctive therapy in patients with symptomatic heart failure

• Post-Myocardial Infarction: To reduce cardiovascular morbidity and mortality

• Cardiovascular Risk Reduction: In patients at high risk of cardiovascular events, including those with diabetes or chronic kidney disease

• Diabetic Nephropathy: To slow the progression of renal disease in patients with type 2 diabetes

Therapeutic Class

• ACE Inhibitor

• Antihypertensive Agent

Pharmacology

Ramipril inhibits the angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II. The resulting vasodilation decreases systemic vascular resistance and lowers blood pressure. Reduced aldosterone secretion promotes sodium and water excretion, contributing to decreased blood volume and cardiac workload.

Ramipril is a prodrug that is metabolized in the liver to its active form, ramiprilat. It is absorbed orally and exhibits a prolonged duration of action, allowing once or twice daily dosing depending on clinical requirements. By modulating the renin-angiotensin-aldosterone system (RAAS), Ramipril provides both antihypertensive and cardioprotective benefits.

Dosage and Administration

• Hypertension: 2.5–10 mg once daily; dose may be increased gradually based on response

• Heart Failure: 1.25–5 mg once daily, titrated according to tolerance

• Cardiovascular Risk Reduction: 2.5 mg once daily, may increase to 10 mg as tolerated

• Special Populations: Dose adjustment may be required in renal impairment

Primace can be taken with or without food. Capsules should be swallowed whole with water. Regular monitoring of blood pressure, renal function, and serum electrolytes is recommended during therapy.

Contraindications

• History of hypersensitivity to ramipril or other ACE inhibitors

• History of angioedema related to previous ACE inhibitor therapy

• Pregnancy (especially during the second and third trimesters)

Adverse Effects

Common side effects may include:

• Cough (dry and persistent)

• Dizziness or hypotension

• Headache

• Fatigue

• Gastrointestinal disturbances such as nausea and diarrhea

• Rash

Rare but serious adverse effects include angioedema, hyperkalemia, and renal impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor renal function and serum potassium regularly

• Use with caution in patients with renal artery stenosis or chronic kidney disease

• Discontinue or adjust dose in cases of hypotension, hyperkalemia, or worsening renal function

• Avoid concurrent use with potassium-sparing diuretics or potassium supplements unless closely monitored

Pregnancy and Lactation

Ramipril is contraindicated during pregnancy, especially in the second and third trimesters, due to risk of fetal toxicity. Safety in breastfeeding is not established; alternative therapy should be considered.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.