Primace Tablet 10 mg contains Ramipril, a widely prescribed angiotensin-converting enzyme (ACE) inhibitor used for the management of hypertension, heart failure, and cardiovascular risk reduction. Ramipril works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby relaxing blood vessels, reducing blood pressure, and decreasing the workload on the heart.

Primace 10 mg is especially beneficial in patients with essential hypertension, post-myocardial infarction, heart failure, or at high risk of cardiovascular events such as stroke or heart attack. Its organ-protective properties help safeguard the heart, kidneys, and brain against damage caused by chronic high blood pressure. By improving hemodynamic stability and endothelial function, Ramipril enhances long-term cardiovascular outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Primace Tablet 10 mg is indicated for:

• Hypertension: Alone or in combination with other antihypertensives to achieve optimal blood pressure control.

• Heart Failure: Management of symptomatic heart failure to improve survival and reduce hospitalizations.

• Post-Myocardial Infarction: Reduces mortality and prevents progression of heart failure after a heart attack.

• Cardiovascular Risk Reduction: Lowers the risk of stroke, myocardial infarction, and cardiovascular death in high-risk patients, including those with diabetes or established vascular disease.

• Renal Protection: Slows progression of diabetic nephropathy and proteinuria by reducing intraglomerular pressure.

Therapeutic Class

Angiotensin-Converting Enzyme (ACE) Inhibitor

Pharmacology

Ramipril is a prodrug that is converted in the liver to its active form, Ramiprilat, which selectively inhibits the angiotensin-converting enzyme. This prevents the formation of angiotensin II, leading to:

• Vasodilation

• Reduced aldosterone secretion

• Natriuresis and diuresis

• Lower blood pressure and reduced cardiac preload and afterload

Additionally, Ramipril improves endothelial function, reduces vascular inflammation, and protects organs such as the heart and kidneys from long-term hypertensive damage. Antihypertensive effects are typically observed within one week, with maximal efficacy reached after 3–6 weeks.

Dosage and Administration

• Hypertension: Initial dose: 2.5–5 mg once daily; may be titrated to 10 mg once daily depending on response.

• Heart Failure/Post-MI: Start with 1.25–2.5 mg once daily, gradually titrated as tolerated.

• Renal or hepatic impairment: Dose adjustments may be necessary.

The tablet should be taken orally at the same time each day, with or without food, to maintain consistent blood levels.

Contraindications

• Known hypersensitivity to Ramipril or other ACE inhibitors

• History of angioedema related to previous ACE inhibitor therapy

• Pregnancy, especially during the second and third trimesters

• Bilateral renal artery stenosis or severe renal impairment

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Persistent dry cough

• Dizziness, hypotension, or fatigue

• Headache and gastrointestinal discomfort

• Hyperkalemia (elevated potassium levels)
  Rarely: angioedema, renal impairment, or liver enzyme elevation

Precautions and Warnings

• Monitor renal function and serum potassium regularly, especially in patients with kidney impairment or on potassium-sparing drugs.

• Use cautiously in patients with hypotension, dehydration, or severe heart failure.

• Discontinue immediately if pregnancy is detected due to risk of fetal harm.

Pregnancy and Lactation

Ramipril is contraindicated during pregnancy, particularly in the second and third trimesters, because of the risk of fetal injury. Limited information is available regarding excretion in human milk; breastfeeding is not recommended during therapy.

Storage Conditions

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Mode of Action

Ramipril inhibits angiotensin-converting enzyme, decreasing angiotensin II levels. This causes vasodilation, lowers aldosterone secretion, reduces blood pressure, and decreases cardiac workload, providing protection to the heart, kidneys, and vascular system.