Primace Tablet 1.25 mg contains Ramipril, a widely used angiotensin-converting enzyme (ACE) inhibitor that helps manage hypertension, heart failure, and reduces the risk of cardiovascular events. It is particularly beneficial for patients at high risk of heart attack, stroke, or diabetic kidney disease. Ramipril lowers blood pressure, decreases strain on the heart, and provides kidney protection, making it an essential therapy in chronic cardiovascular and renal care.

Ramipril works by inhibiting ACE, an enzyme responsible for converting angiotensin I to angiotensin II. Angiotensin II is a powerful vasoconstrictor that increases blood pressure and stimulates aldosterone secretion. By reducing its formation, Primace promotes vasodilation, decreases peripheral resistance, lowers blood pressure, and reduces fluid retention. This dual effect improves cardiac workload and provides protective benefits for the kidneys and vascular system.

The 1.25 mg strength is typically used for initiating therapy in patients who require cautious dose titration, including the elderly or those with renal impairment, ensuring safety while gradually achieving optimal blood pressure control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Primace Tablet 1.25 mg is indicated for:

• Hypertension: To reduce elevated blood pressure and associated cardiovascular risk

• Heart Failure: As adjunctive therapy in patients with symptomatic heart failure

• Post-Myocardial Infarction: To improve survival and prevent further cardiovascular complications

• High Cardiovascular Risk: In patients with diabetes, renal impairment, or multiple risk factors

• Diabetic Nephropathy: To slow the progression of kidney damage in type 2 diabetes patients

Therapeutic Class

• ACE Inhibitor

• Antihypertensive Agent

Pharmacology

Ramipril is a prodrug that is converted in the liver to its active metabolite, ramiprilat. It inhibits ACE, reducing the production of angiotensin II and decreasing aldosterone secretion. This leads to vasodilation, lower blood pressure, and reduced sodium and water retention.

The drug’s action on the renin-angiotensin-aldosterone system (RAAS) not only lowers blood pressure but also provides cardioprotective and renoprotective benefits, making it valuable in patients with heart failure, post-myocardial infarction, or diabetic kidney disease.

Dosage and Administration

• Starting Dose: 1.25 mg once daily, especially in patients sensitive to ACE inhibitors such as the elderly or those with renal impairment

• Maintenance Dose: Can be titrated gradually to 2.5–10 mg daily based on blood pressure response and tolerability

• Can be administered with or without food

• Capsules should be swallowed whole with water

Regular monitoring of blood pressure, renal function, and serum electrolytes is recommended, particularly during dose adjustment or in high-risk patients.

Contraindications

Primace Tablet 1.25 mg should not be used in:

• Patients with hypersensitivity to ramipril or other ACE inhibitors

• Patients with angioedema related to previous ACE inhibitor therapy

• Pregnancy, particularly in the second and third trimesters

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Adverse Effects

Common side effects may include:

• Persistent dry cough

• Dizziness or hypotension

• Fatigue

• Headache

• Gastrointestinal disturbances such as nausea and diarrhea

Serious but rare adverse effects include angioedema, hyperkalemia, and renal impairment. Patients should report any swelling of the face, lips, or throat immediately.

Precautions and Warnings

• Monitor renal function and serum potassium, especially in patients with kidney disease or taking potassium-sparing medications

• Use with caution in patients with bilateral renal artery stenosis

• Avoid abrupt discontinuation; tapering may be necessary in certain clinical scenarios

Pregnancy and Lactation

Ramipril is contraindicated in pregnancy, particularly during the second and third trimesters, due to risk of fetal toxicity. Its safety during breastfeeding is not established, so alternative therapy should be considered for nursing mothers.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.