Renib Tablet 40 mg contains Regorafenib Monohydrate, an oral multi-kinase inhibitor used in the treatment of certain advanced cancers. It is designed for patients with specific types of cancer who have previously received other standard therapies. Renib works by targeting multiple pathways involved in tumor growth, cancer cell proliferation, and angiogenesis (formation of new blood vessels that supply tumors).

Regorafenib is widely used in oncology practice for its ability to slow disease progression and help extend survival in selected patients with advanced malignancies.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regorafenib Monohydrate equivalent to Regorafenib 40 mg per tablet

Mechanism of Action

Regorafenib is a multi-targeted tyrosine kinase inhibitor. It blocks several protein kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. By inhibiting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), and other kinases, Renib reduces blood supply to tumors and interferes with cancer cell growth and survival.

This multi-pathway inhibition contributes to slowing tumor progression in advanced-stage cancers.

Indications

Renib Tablet 40 mg is indicated for:

• Metastatic colorectal cancer (after failure of standard therapies)

• Gastrointestinal stromal tumors (GIST) previously treated with other targeted therapies

• Hepatocellular carcinoma (liver cancer) after prior systemic treatment

• Other approved oncological indications as prescribed by a specialist

Treatment should be initiated and supervised by an experienced oncologist.

Dosage and Administration

The recommended dose is usually 160 mg once daily (four 40 mg tablets) for 21 consecutive days followed by 7 days off treatment, constituting a 28-day cycle. Dosage adjustments may be required based on tolerability and adverse reactions.

Renib should be taken at the same time each day with a low-fat meal. Tablets should be swallowed whole with water and not crushed or chewed.

Regular monitoring of liver function, blood pressure, and other laboratory parameters is essential during treatment.

Benefits

• Slows progression of certain advanced cancers

• Targets multiple tumor growth pathways

• Oral administration for outpatient convenience

• Extends progression-free survival in selected patients

• Provides an additional option after standard therapies

Precautions

Renib should be used cautiously in patients with liver impairment, cardiovascular disease, or hypertension. Liver function tests should be monitored frequently, especially during the first two months of treatment.

Patients should inform their healthcare provider about any history of bleeding disorders, recent surgery, or gastrointestinal perforation. Women of childbearing potential should use effective contraception during treatment and for a period after discontinuation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Fatigue

• Hand-foot skin reaction

• Diarrhea

• Hypertension

• Decreased appetite

• Liver enzyme elevation

Serious adverse reactions such as severe liver injury, bleeding, or gastrointestinal perforation require immediate medical attention.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Renib Tablet 40 mg offers a targeted therapeutic option for advanced cancers, supporting disease management under specialized oncology care.