Respira Tablet 1 mg contains Levosalbutamol, the R-enantiomer of salbutamol, a selective β2-adrenergic receptor agonist used for the management of respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchospasm. Levosalbutamol acts by relaxing bronchial smooth muscles, leading to bronchodilation and improved airflow, making it easier for patients to breathe.

As an oral formulation, Respira Tablet is particularly useful for patients who are unable to use inhalation therapy consistently or require adjunct therapy for long-term management of bronchospastic disorders. Compared to racemic salbutamol, levosalbutamol provides similar bronchodilation with potentially fewer cardiovascular side effects due to its selective β2 activity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Selective β2-Adrenergic Receptor Agonist (Bronchodilator)

Indications

Respira Tablet 1 mg is indicated for:

• Asthma: For prevention and treatment of bronchospasm in adults and children

• Chronic Obstructive Pulmonary Disease (COPD): Relief of reversible airflow obstruction

• Exercise-Induced Bronchospasm: Prevention of exercise-related bronchospasm in susceptible patients

• Other Bronchospastic Disorders: Where bronchodilation is therapeutically beneficial

Pharmacology

Levosalbutamol selectively binds to β2-adrenergic receptors in bronchial smooth muscle, activating adenylate cyclase and increasing cyclic AMP levels. This results in relaxation of bronchial smooth muscle, decreased airway resistance, and bronchodilation. Unlike non-selective β-agonists, levosalbutamol has minimal activity on β1 receptors in the heart, reducing the risk of tachycardia and other cardiovascular side effects.

Levosalbutamol is rapidly absorbed after oral administration, metabolized primarily in the liver, and excreted mainly in the urine. Its bronchodilator effect typically begins within 30–60 minutes, lasting for 6–8 hours, making it suitable for maintenance therapy and symptom relief.

Mode of Action

• Selective β2 stimulation: Causes relaxation of bronchial smooth muscles

• Increases cyclic AMP: Reduces intracellular calcium, promoting bronchodilation

• Improves airflow: Reduces wheezing, shortness of breath, and bronchospasm

Dosage and Administration

• Usual Adult Dose: 1 mg orally two to three times daily, as directed by a physician

• Pediatric Dose: Determined by age and weight; follow physician’s guidance

• Administration: Can be taken with or without food

• Adjustment: Dose may be modified based on severity of symptoms and clinical response

• Monitoring: Patients should be monitored for effectiveness and potential side effects

Drug Interactions

• Non-selective β-blockers: May reduce bronchodilator effect

• Diuretics: May potentiate hypokalemia

• MAO inhibitors or tricyclic antidepressants: May increase risk of cardiovascular side effects

• Other sympathomimetics: Caution for additive effects

Contraindications

• Hypersensitivity to levosalbutamol or any component of the tablet

• Severe cardiac disorders (e.g., arrhythmias, tachycardia) requiring caution

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Tremor or muscle cramps

• Headache

• Palpitations or mild tachycardia

• Nervousness or restlessness

• Gastrointestinal discomfort

Rare side effects may include hypersensitivity reactions, arrhythmias, or hypokalemia. Most adverse effects are mild and dose-dependent.

Pregnancy and Lactation

• Pregnancy: Use only if clearly needed; no well-controlled human studies available

• Lactation: Small amounts may be excreted in breast milk; weigh the benefits against potential risks

Precautions and Warnings

• Use with caution in patients with cardiovascular disorders, hyperthyroidism, or diabetes

• Monitor heart rate and blood pressure during therapy

• Avoid abrupt discontinuation in chronic therapy

• Patients experiencing severe tremors, chest pain, or palpitations should seek medical attention

Storage Conditions

Store in a cool, dry place below 30°C.
Protect from light and moisture. Keep out of reach of children.