Reumafen 100 mg/5 ml is a versatile non-steroidal anti-inflammatory drug (NSAID) available in both oral and topical formulations. It is designed to relieve pain, reduce inflammation, and lower fever in a variety of musculoskeletal, rheumatologic, and soft tissue conditions. The oral suspension is ideal for systemic management of inflammatory disorders, while the topical gel provides targeted relief in localized musculoskeletal pain and joint inflammation.

Reumafen works by inhibiting cyclooxygenase (COX) enzymes, which decreases the synthesis of prostaglandins responsible for pain, swelling, and fever. Its anti-inflammatory, analgesic, and antipyretic effects make it effective in conditions ranging from arthritis and low back pain to dysmenorrhea and migraine.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Drugs for Osteoarthritis

• Drugs used for Rheumatoid Arthritis

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

Oral Suspension:

• Rheumatoid arthritis, osteoarthritis, gouty arthritis

• Juvenile polyarthritis and ankylosing spondylitis

• Synovitis, low back pain, soft tissue injuries

• Dysmenorrhea, fever, migraine

• Pain and inflammation of dental or musculoskeletal origin

Topical Gel (5%):

• Musculoskeletal pain, rheumatic and muscular pain

• Sprains, strains, and sports injuries

• Non-serious arthritic conditions and neuralgia

Pharmacology

Reumafen is a non-selective COX inhibitor, reducing prostaglandin production through the arachidonic acid pathway. Inhibition of COX-2 provides relief from inflammation and pain, while COX-1 inhibition can contribute to gastrointestinal side effects. The drug exists as a racemic mixture, with the S-enantiomer being the more pharmacologically active form. Its central and peripheral effects provide rapid analgesic action, reduce stiffness, and improve joint mobility in arthritic conditions.

Mode of Action

• Peripheral Action: Reduces prostaglandin-mediated inflammation and pain in tissues

• Central Action: Modulates pain perception pathways in the nervous system

• Analgesic & Anti-inflammatory: Quickly relieves pain, swelling, and stiffness

Dosage and Administration

Oral Administration:

• Children: 20 mg/kg/day in divided doses (max 500 mg/day for <30 kg)

  • 1–2 years: ½ tsp (2.5 ml) 3–4 times daily

  • 3–7 years: 1 tsp (5 ml) 3–4 times daily

  • 8–12 years: 2 tsp (10 ml) 3–4 times daily

• Adults: 400 mg 3–4 times daily, up to 2.4 g/day depending on severity

Topical Gel:

• Apply 4–10 cm of gel (equivalent to 50–125 mg) to affected area 3–4 times daily

• Massage until absorbed; do not apply on broken skin, genital area, or near eyes

General Guidelines:

• Take oral doses with food or milk to reduce gastrointestinal irritation

• Monitor for response and adjust dosage as needed

Drug Interactions

• Warfarin, corticosteroids, SSRIs, aspirin: Increased risk of gastrointestinal bleeding

• Diuretics: May reduce natriuretic effect

• ACE inhibitors/ARBs: May reduce antihypertensive effect

• Lithium and methotrexate: Increased toxicity risk

• Ciclosporin and tacrolimus: Increased nephrotoxicity

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Reumafen or other NSAIDs

• Severe or active peptic ulceration

• Pregnancy and lactation (unless benefits outweigh risks)

Side Effects

• Common: Nausea, vomiting, heartburn, upset stomach

• Rare: Gastrointestinal bleeding, allergic reactions, liver enzyme abnormalities

Precautions & Warnings

• Use the lowest effective dose for patients with a history of GI hemorrhage or ulcer

• Regular ocular monitoring may be required in long-term therapy

• Caution in asthma, systemic lupus erythematosus, or hypersensitivity to other NSAIDs

Overdose

• Symptomatic management: Gastric lavage and correction of electrolyte imbalance

• No specific antidote

Storage Conditions

Store in a cool, dry place protected from light. Keep out of reach of children.