Ribox 120 mg is an oral non-steroidal anti-inflammatory drug (NSAID) designed for the management of pain, inflammation, and related symptoms in various musculoskeletal and inflammatory disorders. It is a selective cyclooxygenase-2 (COX-2) inhibitor, offering anti-inflammatory, analgesic, and antipyretic effects with a reduced risk of gastrointestinal toxicity compared to non-selective NSAIDs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

• COX-2 Selective Inhibitor

Indications

Ribox 120 mg is indicated for symptomatic relief and management of conditions associated with pain and inflammation, including:

• Osteoarthritis (OA): Relieves joint pain, stiffness, and inflammation.

• Rheumatoid Arthritis (RA): Reduces pain, swelling, and inflammation in joints.

• Ankylosing Spondylitis: Helps manage chronic spinal inflammation and stiffness.

• Acute Gouty Arthritis: Eases pain and inflammation during flare-ups.

• Dental Surgery Pain: Provides short-term relief of moderate post-operative pain.

Pharmacology & Mode of Action

Ribox 120 mg selectively inhibits COX-2, the enzyme primarily responsible for producing prostanoids that mediate pain, inflammation, and fever. Unlike non-selective NSAIDs, Ribox has minimal inhibition of COX-1, reducing gastrointestinal adverse effects and avoiding significant effects on platelet aggregation.

• Analgesic: Reduces pain by lowering prostaglandin synthesis at sites of inflammation.

• Anti-inflammatory: Alleviates swelling and joint stiffness by targeting inflammatory pathways.

• Antipyretic: Lowers fever through central and peripheral prostaglandin suppression.

Dosage & Administration

Adults and Adolescents (≥16 years):

• Osteoarthritis: 30 mg once daily, may increase to 60 mg if needed.

• Rheumatoid Arthritis / Ankylosing Spondylitis: 90 mg once daily.

• Acute Gouty Arthritis: 120 mg once daily (typically up to 8 days).

• Postoperative Dental Pain: 90 mg once daily for up to 3 days.

• Administration: Oral, with or without food. Use the lowest effective dose for the shortest duration to minimize cardiovascular and gastrointestinal risks.

Drug Interactions

• Oral anticoagulants (e.g., warfarin): May increase prothrombin time; monitor closely.

• Diuretics, ACE inhibitors, ARBs: NSAIDs may reduce antihypertensive efficacy.

• Aspirin: Low-dose aspirin may be co-administered for cardiovascular prophylaxis.

• Ciclosporin / Tacrolimus: Increased risk of nephrotoxicity.

• Lithium: May increase plasma lithium levels.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Ribox or excipients

• Active peptic ulcer or GI bleeding

• Severe hepatic or renal impairment

• Children <16 years

• Pregnancy and lactation

• History of cardiovascular disease, uncontrolled hypertension, or congestive heart failure

• Inflammatory bowel disease

Side Effects

Common and less common adverse effects include:

• Palpitations, fatigue, dizziness, nausea, and diarrhea

• Influenza-like symptoms, flushing, dry mouth

• Rare: Confusion, hallucinations, atrial fibrillation, transient ischemic attack

Precautions & Warnings

• Gastrointestinal Risk: Elderly and patients with history of ulcers should use caution.

• Cardiovascular Risk: Monitor patients with hypertension, hyperlipidemia, diabetes, or prior cardiac events.

• Renal & Hepatic Monitoring: Assess function periodically, especially in patients with pre-existing conditions.

• Hypersensitivity: Discontinue at first sign of rash or mucosal lesions.

Pregnancy & Lactation

• Pregnancy: Avoid, especially in the third trimester due to risk of premature ductus arteriosus closure.

• Lactation: Not recommended; Ribox is excreted in breast milk.

Overdose

• Supportive therapy is recommended.

• Single doses up to 500 mg and repeated doses up to 150 mg/day for 21 days have not shown significant toxicity.

Storage Conditions

• Store below 30°C, protected from light and moisture.

• Keep out of reach of children.